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Tbio
PWP1
Periodic tryptophan protein 1 homolog

Protein Summary
Description
Chromatin-associated factor that regulates transcription (PubMed:29065309). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309). Regulates the epigenetic status of rDNA (PubMed:29065309). The protein encoded by this gene contains several WD-40 repeats and is found mostly in the nucleus. The expression and localization of this protein are cell cycle dependent. Expression of this gene is upregulated in pancreatic adenocarcinoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000412830
  • ENSP00000387365
  • ENSG00000136045
  • ENST00000552760
  • ENSP00000448227

Symbol
  • IEF-SSP-9502
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
hub protein
0.99
interacting protein
0.98
kinase perturbation
0.98
co-expressed gene
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (335)
ANK3
Tbio
Novelty:  0.00429246
p_int:  0.99906317
p_ni:  0.00093683
Score:  0.255
Data Source:  BioPlex,STRINGDB
LGALS13
Tbio
Novelty:  0.00695816
p_int:  0.997639531
p_ni:  0.002353726
p_wrong:  0.000006743
Score:  0.309
Data Source:  BioPlex,STRINGDB
RPL15
Tbio
Novelty:  0.02466708
p_int:  0.992815623
p_ni:  0.007184377
Score:  0.598
Data Source:  BioPlex,STRINGDB
RPL7A
Tbio
Novelty:  0.01674027
p_int:  0.943640632
p_ni:  0.056359368
Score:  0.355
Data Source:  BioPlex,STRINGDB
TCAF1
Tbio
Family:  Enzyme
Novelty:  0.50366212
p_int:  0.920154287
p_ni:  0.079845713
Score:  0.346
Data Source:  BioPlex,STRINGDB
FTSJ3
Tbio
Family:  Enzyme
Novelty:  0.01888973
Score:  0.985
Data Source:  STRINGDB
DDX10
Tbio
Family:  Enzyme
Novelty:  0.03272208
Score:  0.983
Data Source:  STRINGDB
PES1
Tbio
Novelty:  0.07162845
Score:  0.981
Data Source:  STRINGDB
PUM3
Tbio
Novelty:  0.02344206
Score:  0.979
Data Source:  STRINGDB
DDX24
Tbio
Family:  Enzyme
Novelty:  0.17803446
Score:  0.979
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
64
monocyte percentage of leukocytes
1
1
1
4.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
64
monocyte percentage of leukocytes
1
4.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PWP1 homolog, endonuclein
VGNC:5557
452207
Mouse
MGI:1914735
103136
Rat
RGD:1310705
362856
Dog
PWP1 homolog, endonuclein
VGNC:45215
474526
Horse
PWP1 homolog, endonuclein
VGNC:22052
100054049
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PWP1 homolog, endonuclein
Mouse
Rat
Dog
PWP1 homolog, endonuclein
Horse
PWP1 homolog, endonuclein
Publication Statistics
PubMed Score 16.48
PubMed score by year
PubTator Score 3.54
PubTator score by year
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Related Publications
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PMID
Year
Title