Tbio PVRIG Transmembrane protein PVRIG

Protein Summary

Description

Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.

Uniprot Accession IDs

• Q6DKI7
• D6W5U9
• Q9BVK3

Gene Name

• PVRIG

Ensembl ID

• ENST00000317271
• ENSP00000316675
• ENSG00000213413

Symbol

• C7orf15
• CD112R
• C7orf15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.94
cell line	0.64
tissue sample	0.64
tissue	0.49
transcription factor binding site profile	0.47

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.84   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 80   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.84   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0