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Tbio
PVR
Poliovirus receptor

Protein Summary
Description
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344956
  • ENSP00000340870
  • ENSG00000073008
  • ENST00000403059
  • ENSP00000385344

Symbol
  • PVS
  • PVS
  • HVED
  • CD155
  • NECL5
  • TAGE4
  • Necl-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
transcription factor perturbation
0.99
small molecule perturbation
0.9
kinase perturbation
0.76
histone modification site profile
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.04   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 568   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.04   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 568   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
NLRX1
Tbio
Novelty:  0.00906898
p_int:  0.999976427
p_ni:  0.000023573
Data Source:  BioPlex
C4A
Tbio
Novelty:  0.00062793
p_int:  0.999917355
p_ni:  0.000082645
p_wrong:  1e-9
Score:  0.199
Data Source:  BioPlex,STRINGDB
UBE2C
Tbio
Novelty:  0.00731185
p_int:  0.99984296
p_ni:  0.000010905
p_wrong:  0.000146136
Score:  0.195
Data Source:  BioPlex,STRINGDB
RYK
Tbio
Family:  Kinase
Novelty:  0.00910227
p_int:  0.999801544
p_ni:  0.000083559
p_wrong:  0.000114897
Data Source:  BioPlex
CDON
Tbio
Novelty:  0.00447262
p_int:  0.999683458
p_ni:  0.000148361
p_wrong:  0.000168181
Score:  0.164
Data Source:  BioPlex,STRINGDB
PI4K2A
Tbio
Family:  Kinase
Novelty:  0.03506675
p_int:  0.999300563
p_ni:  0.00065699
p_wrong:  0.000042446
Score:  0.157
Data Source:  BioPlex,STRINGDB
RAB5B
Tbio
Family:  Enzyme
Novelty:  0.02653775
p_int:  0.999245225
p_ni:  0.000754772
p_wrong:  3e-9
Score:  0.194
Data Source:  BioPlex,STRINGDB
LRBA
Tbio
Novelty:  0.00093369
p_int:  0.999217997
p_ni:  0.000781916
p_wrong:  8.8e-8
Data Source:  BioPlex
FBXL20
Tbio
Novelty:  0.092544
p_int:  0.999012067
p_ni:  0.000389524
p_wrong:  0.000598409
Score:  0.177
Data Source:  BioPlex,STRINGDB
GNPAT
Tchem
Family:  Enzyme
Novelty:  0.01255689
p_int:  0.99649384
p_ni:  0.00350616
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
21
21
100
low density lipoprotein cholesterol measurement
4
19
23
99.9
total cholesterol measurement
2
15
18
99.9
2
15
0
7.1
98.7
family history of Alzheimer’s disease
1
13
0
7.4
98.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
21
100
low density lipoprotein cholesterol measurement
23
99.9
total cholesterol measurement
18
99.9
0
7.1
98.7
family history of Alzheimer’s disease
0
7.4
98.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poliovirus receptor
VGNC:2268
744055
Macaque
poliovirus receptor
712851
Dog
poliovirus receptor
476439
Horse
poliovirus receptor homolog
100070567
Pig
poliovirus receptor homolog
100525346
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poliovirus receptor
Macaque
poliovirus receptor
Dog
poliovirus receptor
Horse
poliovirus receptor homolog
Pig
poliovirus receptor homolog
Publication Statistics
PubMed Score 450.04
PubMed score by year
PubTator Score 372.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title