Protein Summary
In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
- ENST00000216200
- ENSP00000216200
- ENSG00000100362
- ENST00000417718
- ENSP00000400247
- ENST00000620986
- ENSP00000480913
- ENSG00000274665
- ENST00000625893
- ENSP00000486144
- D22S749
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.83 | ||
disease perturbation | 0.68 | ||
PubMedID | 0.59 | ||
protein domain | 0.58 | ||
cellular component | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3861.34 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 306 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3861.34 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 306 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (317)
SREBF1
Family: TF
Novelty: 0.00055257
p_int: 0.998504372
p_ni: 0.00147592
p_wrong: 0.000019707
Score: 0.693
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | Transcriptional Regulation by MECP2 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
Transcriptional Regulation by MECP2 | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (3)
Components (5)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 4 | 5 | 6 | 96.7 | |||||
eosinophil percentage of leukocytes | 2 | 4 | 5 | 88.3 | |||||
sum of eosinophil and basophil counts | 1 | 1 | 1 | 60.2 | |||||
1 | 2 | 0 | 1.1 | 59.4 | |||||
eosinophil percentage of granulocytes | 1 | 1 | 1 | 45.2 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 6 | 96.7 | |||||
eosinophil percentage of leukocytes | 5 | 88.3 | |||||
sum of eosinophil and basophil counts | 1 | 60.2 | |||||
0 | 1.1 | 59.4 | |||||
eosinophil percentage of granulocytes | 1 | 45.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | parvalbumin | 697272 | ||||||
Mouse | MGI:97821 | 19293 | ||||||
Rat | RGD:3457 | 25269 | ||||||
Dog | parvalbumin | VGNC:45214 | 481278 | |||||
Horse | parvalbumin | VGNC:22051 | 100069554 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | parvalbumin | |||||
Mouse | ||||||
Rat | ||||||
Dog | parvalbumin | |||||
Horse | parvalbumin | |||||
Publication Statistics
PubMed Score 3861.34
PubMed score by year
PubTator Score 832.92
PubTator score by year
Related Publications
Text Mined References (43)
GeneRif Annotations (26)
Items per page:
0 of 0
PMID | Year | Title |
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