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Tbio
PVALB
Parvalbumin alpha

Protein Summary
Description
In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216200
  • ENSP00000216200
  • ENSG00000100362
  • ENST00000417718
  • ENSP00000400247
  • ENST00000620986
  • ENSP00000480913
  • ENSG00000274665
  • ENST00000625893
  • ENSP00000486144

Symbol
  • D22S749
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
disease perturbation
0.68
PubMedID
0.59
protein domain
0.58
cellular component
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3861.34   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3861.34   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (317)
SREBF1
Tbio
Family:  TF
Novelty:  0.00055257
p_int:  0.998504372
p_ni:  0.00147592
p_wrong:  0.000019707
Score:  0.693
Data Source:  BioPlex,STRINGDB
CALB1
Tbio
Novelty:  0.00037716
Score:  0.945
Data Source:  STRINGDB
CALB2
Tbio
Novelty:  0.0004996
Score:  0.944
Data Source:  STRINGDB
SST
Tbio
Novelty:  0.00005944
Score:  0.923
Data Source:  STRINGDB
GAD1
Tbio
Family:  Enzyme
Novelty:  0.00067443
Score:  0.901
Data Source:  STRINGDB
CCK
Tbio
Novelty:  0.00012268
Score:  0.87
Data Source:  STRINGDB
GAD2
Tbio
Family:  Enzyme
Novelty:  0.00058427
Score:  0.865
Data Source:  STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.85
Data Source:  STRINGDB
SDF4
Tbio
Novelty:  0.00105893
Score:  0.831
Data Source:  STRINGDB
GRIN1
Tclin
Family:  IC
Novelty:  0.0011807
Score:  0.815
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Transcriptional Regulation by MECP2
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Transcriptional Regulation by MECP2
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
5
6
96.7
eosinophil percentage of leukocytes
2
4
5
88.3
sum of eosinophil and basophil counts
1
1
1
60.2
1
2
0
1.1
59.4
eosinophil percentage of granulocytes
1
1
1
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
6
96.7
eosinophil percentage of leukocytes
5
88.3
sum of eosinophil and basophil counts
1
60.2
0
1.1
59.4
eosinophil percentage of granulocytes
1
45.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
parvalbumin
697272
Mouse
MGI:97821
19293
Rat
RGD:3457
25269
Dog
parvalbumin
VGNC:45214
481278
Horse
parvalbumin
VGNC:22051
100069554
Species
Name
OMA
EggNOG
Inparanoid
Macaque
parvalbumin
Mouse
Rat
Dog
parvalbumin
Horse
parvalbumin
Publication Statistics
PubMed Score 3861.34
PubMed score by year
PubTator Score 832.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title