PVALB
Parvalbumin alpha
Protein Summary
In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
- ENST00000216200
- ENSP00000216200
- ENSG00000100362
- ENST00000417718
- ENSP00000400247
- ENST00000620986
- ENSP00000480913
- ENSG00000274665
- ENST00000625893
- ENSP00000486144
- D22S749
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.83 | ||
disease perturbation | 0.68 | ||
PubMedID | 0.59 | ||
protein domain | 0.58 | ||
cellular component | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4188.58 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 306 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4188.58 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 306 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0