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Tdark
PUSL1
tRNA pseudouridine synthase-like 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379031
  • ENSP00000368318
  • ENSG00000169972
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
protein domain
0.73
tissue sample
0.6
histone modification site profile
0.52
interacting protein
0.5


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.5   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.5   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
KCTD12
Tchem
Novelty:  0.0386637
p_int:  0.999943906
p_ni:  0.000056091
p_wrong:  4e-9
Data Source:  BioPlex
CAMK2D
Tchem
Family:  Kinase
Novelty:  0.02326864
p_int:  0.999920913
p_ni:  0.000079075
p_wrong:  1.2e-8
Data Source:  BioPlex
TRIP13
Tbio
Family:  Enzyme
Novelty:  0.00660506
p_int:  0.99978115
p_ni:  0.000218841
p_wrong:  8e-9
Score:  0.229
Data Source:  BioPlex,STRINGDB
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.999053345
p_ni:  0.000946651
p_wrong:  4e-9
Score:  0.345
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.998167584
p_ni:  0.001831765
p_wrong:  6.52e-7
Score:  0.209
Data Source:  BioPlex,STRINGDB
ISOC2
Tbio
Family:  Enzyme
Novelty:  0.33841868
p_int:  0.997819309
p_ni:  0.001604872
p_wrong:  0.000575819
Score:  0.245
Data Source:  BioPlex,STRINGDB
GCHFR
Tbio
Family:  Enzyme
Novelty:  0.04287433
p_int:  0.995527648
p_ni:  0.00446523
p_wrong:  0.000007122
Score:  0.189
Data Source:  BioPlex,STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.993512976
p_ni:  0.005749229
p_wrong:  0.000737795
Score:  0.174
Data Source:  BioPlex,STRINGDB
CROCC
Tbio
Novelty:  0.03718561
p_int:  0.991113786
p_ni:  0.008441057
p_wrong:  0.000445157
Score:  0.177
Data Source:  BioPlex,STRINGDB
PLCD4
Tbio
Family:  Enzyme
Novelty:  0.07014141
p_int:  0.987194359
p_ni:  0.012774309
p_wrong:  0.000031332
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
56.2
intraocular pressure measurement
1
2
2
52.7
1
1
0
1.1
35
hair color
1
1
0
1.1
8.6
heel bone mineral density
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
56.2
intraocular pressure measurement
2
52.7
0
1.1
35
hair color
0
1.1
8.6
heel bone mineral density
1
6.7
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pseudouridylate synthase-like 1
457190
Macaque
pseudouridylate synthase-like 1
705127
Mouse
MGI:3047787
433813
Dog
pseudouridylate synthase like 1
VGNC:49842
100856118
Horse
pseudouridylate synthase like 1
VGNC:50747
100065961
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pseudouridylate synthase-like 1
Macaque
pseudouridylate synthase-like 1
Mouse
Dog
pseudouridylate synthase like 1
Horse
pseudouridylate synthase like 1
Publication Statistics
PubMed Score 0.50
PubMed score by year
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Related Publications
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PMID
Year
Title