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Tbio
PUS1
tRNA pseudouridine synthase A

Protein Summary
Description
Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 RNA. This gene encodes a pseudouridine synthase that converts uridine to pseudouridine once it has been incorporated into an RNA molecule. The encoded enzyme may play an essential role in tRNA function and in stabilizing the secondary and tertiary structure of many RNAs. A mutation in this gene has been linked to mitochondrial myopathy and sideroblastic anemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376649
  • ENSP00000365837
  • ENSG00000177192
  • ENST00000443358
  • ENSP00000392451

Symbol
  • MLASA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
kinase perturbation
0.91
virus perturbation
0.79
gene perturbation
0.76
protein domain
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.7   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.7   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (159)
PARP8
Tdark
Family:  Enzyme
Novelty:  0.29808738
p_int:  0.999973744
p_ni:  0.000026256
Data Source:  BioPlex
THUMPD3
Tdark
Novelty:  0.23224828
p_int:  0.999957136
p_ni:  0.000042864
Score:  0.378
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.999853716
p_ni:  0.000146284
Score:  0.407
Data Source:  BioPlex,STRINGDB
ZNF664
Tdark
Family:  TF
Novelty:  0.25879878
p_int:  0.999689092
p_ni:  0.000310908
Data Source:  BioPlex
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.999645856
p_ni:  0.000354144
Data Source:  BioPlex
THUMPD1
Tdark
Novelty:  0.19420931
p_int:  0.998655509
p_ni:  0.001344491
Score:  0.366
Data Source:  BioPlex,STRINGDB
TRPV5
Tchem
Family:  IC
Novelty:  0.0055156
p_int:  0.997533593
p_ni:  0.002466407
Score:  0.225
Data Source:  BioPlex,STRINGDB
NUP133
Tbio
Novelty:  0.02115225
p_int:  0.995466887
p_ni:  0.004533113
Score:  0.157
Data Source:  BioPlex,STRINGDB
KLF5
Tchem
Family:  TF
Novelty:  0.00384971
p_int:  0.987477042
p_ni:  0.012522958
Data Source:  BioPlex
ABCD4
Tbio
Family:  Transporter
Novelty:  0.04096359
p_int:  0.984268329
p_ni:  0.015731671
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (37)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the mitochondrion
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the mitochondrion
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
1
3
47.4
mean corpuscular volume
1
1
1
34.9
mean reticulocyte volume
1
1
1
34.7
mathematical ability
1
1
1
21.5
mean corpuscular hemoglobin concentration
1
1
1
17.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
47.4
mean corpuscular volume
1
34.9
mean reticulocyte volume
1
34.7
mathematical ability
1
21.5
mean corpuscular hemoglobin concentration
1
17.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pseudouridylate synthase 1
VGNC:5556
738455
Macaque
pseudouridylate synthase 1
719360
Mouse
MGI:1929237
56361
Rat
RGD:1311871
304567
Dog
pseudouridylate synthase 1
VGNC:45210
609867
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pseudouridylate synthase 1
Macaque
pseudouridylate synthase 1
Mouse
Rat
Dog
pseudouridylate synthase 1
Publication Statistics
PubMed Score 53.70
PubMed score by year
PubTator Score 22.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title