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Tbio
PURB
Transcriptional activator protein Pur-beta

Protein Summary
Description
Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Dele ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395699
  • ENSP00000379051
  • ENSG00000146676

Symbol
  • PURBETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor binding site profile
0.92
small molecule perturbation
0.88
transcription factor perturbation
0.84
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.44   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.44   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.997801757
p_ni:  0.002198223
p_wrong:  2e-8
Score:  0.542
Data Source:  BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.984708215
p_ni:  0.010078643
p_wrong:  0.005213143
Score:  0.17
Data Source:  BioPlex,STRINGDB
CD1A
Tbio
Novelty:  0.00090676
p_int:  0.973218777
p_ni:  0.026777649
p_wrong:  0.000003574
Data Source:  BioPlex
CNOT7
Tchem
Novelty:  0.04551853
p_int:  0.972383875
p_ni:  0.009461695
p_wrong:  0.018154431
Score:  0.233
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.944179144
p_ni:  0.055820852
p_wrong:  4e-9
Score:  0.291
Data Source:  BioPlex,STRINGDB
RPSA
Tbio
Novelty:  0.00250446
p_int:  0.942429013
p_ni:  0.030615895
p_wrong:  0.026955092
Score:  0.762
Data Source:  BioPlex,STRINGDB
RPS13
Tbio
Novelty:  0.0019983
p_int:  0.828784926
p_ni:  0.103603574
p_wrong:  0.0676115
Data Source:  BioPlex
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.80910179
p_ni:  0.190898205
p_wrong:  6e-9
Score:  0.447
Data Source:  BioPlex,STRINGDB
PURA
Tbio
Novelty:  0.00660312
Score:  0.983
Data Source:  STRINGDB
RFC3
Tbio
Novelty:  0.02712951
Score:  0.833
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
86.5
platelet count
3
3
3
86
neutrophil count
4
2
4
79.9
mean reticulocyte volume
1
1
1
76.5
mean corpuscular volume
1
1
1
76.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
86.5
platelet count
3
86
neutrophil count
4
79.9
mean reticulocyte volume
1
76.5
mean corpuscular volume
1
76.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
purine rich element binding protein B
VGNC:14070
472357
Mouse
MGI:1338779
19291
Rat
RGD:1559465
498407
Cow
purine rich element binding protein B
VGNC:33573
504276
Opossum
purine rich element binding protein B
100024737
Species
Name
OMA
EggNOG
Inparanoid
Chimp
purine rich element binding protein B
Mouse
Rat
Cow
purine rich element binding protein B
Opossum
purine rich element binding protein B
Publication Statistics
PubMed Score 50.44
PubMed score by year
PubTator Score 9.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title