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Tbio
PUM3
Pumilio homolog 3

Protein Summary
Description
Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397885
  • ENSP00000380982
  • ENSG00000080608

Symbol
  • cPERP-C
  • KIAA0020
  • PUF-A
  • XTP5
  • PEN
  • HA-8
  • PUF6
  • XTP5
  • PUF-A
  • HLA-HA8
  • KIAA0020
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.14   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.14   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (414)
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.999857109
p_ni:  0.000142891
Data Source:  BioPlex
RPL14
Tbio
Novelty:  0.01600377
p_int:  0.999217667
p_ni:  0.000782333
Score:  0.366
Data Source:  BioPlex,STRINGDB
RPL18A
Tbio
Novelty:  0.04612948
p_int:  0.99901895
p_ni:  0.00098105
Score:  0.539
Data Source:  BioPlex,STRINGDB
RPL8
Tbio
Novelty:  0.01064076
p_int:  0.998054454
p_ni:  0.001945546
Score:  0.665
Data Source:  BioPlex,STRINGDB
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.996644852
p_ni:  0.003355148
Score:  0.95
Data Source:  BioPlex,STRINGDB
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.996159257
p_ni:  0.003840743
Score:  0.933
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.99474091
p_ni:  0.00525909
Score:  0.36
Data Source:  BioPlex,STRINGDB
RPL28
Tbio
Novelty:  0.03136035
p_int:  0.993801334
p_ni:  0.006198666
Score:  0.335
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.993226897
p_ni:  0.006773103
Score:  0.371
Data Source:  BioPlex,STRINGDB
ZNF2
Tbio
Family:  TF
Novelty:  0.01062543
p_int:  0.99252828
p_ni:  0.00747172
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vascular endothelial growth factor measurement
3
5
5
98.2
hemoglobin measurement
3
3
3
92.3
hematocrit
3
2
3
89.5
low density lipoprotein cholesterol measurement
6
1
6
75.9
platelet count
1
1
1
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vascular endothelial growth factor measurement
5
98.2
hemoglobin measurement
3
92.3
hematocrit
3
89.5
low density lipoprotein cholesterol measurement
6
75.9
platelet count
1
74.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pumilio RNA binding family member 3
VGNC:4841
464968
Macaque
pumilio RNA binding family member 3
696063
Mouse
MGI:106253
52874
Rat
RGD:1308750
294066
Dog
pumilio RNA binding family member 3
VGNC:45208
476337
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pumilio RNA binding family member 3
Macaque
pumilio RNA binding family member 3
Mouse
Rat
Dog
pumilio RNA binding family member 3
Publication Statistics
PubMed Score 48.14
PubMed score by year
PubTator Score 2622.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title