Protein Summary
Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity).
- ENST00000397885
- ENSP00000380982
- ENSG00000080608
- cPERP-C
- KIAA0020
- PUF-A
- XTP5
- PEN
- HA-8
- PUF6
- XTP5
- PUF-A
- HLA-HA8
- KIAA0020
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.14 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 105 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.14 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 105 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (414)
RPL14
Novelty: 0.01600377
p_int: 0.999217667
p_ni: 0.000782333
Score: 0.366
Data Source: BioPlex,STRINGDB
RPL18A
Novelty: 0.04612948
p_int: 0.99901895
p_ni: 0.00098105
Score: 0.539
Data Source: BioPlex,STRINGDB
RPL8
Novelty: 0.01064076
p_int: 0.998054454
p_ni: 0.001945546
Score: 0.665
Data Source: BioPlex,STRINGDB
RBM34
Novelty: 0.58131282
p_int: 0.996644852
p_ni: 0.003355148
Score: 0.95
Data Source: BioPlex,STRINGDB
RRP8
Family: Enzyme
Novelty: 0.04922797
p_int: 0.996159257
p_ni: 0.003840743
Score: 0.933
Data Source: BioPlex,STRINGDB
RPL26L1
Novelty: 0.75408617
p_int: 0.99474091
p_ni: 0.00525909
Score: 0.36
Data Source: BioPlex,STRINGDB
RPL28
Novelty: 0.03136035
p_int: 0.993801334
p_ni: 0.006198666
Score: 0.335
Data Source: BioPlex,STRINGDB
RPL30
Novelty: 0.0134194
p_int: 0.993226897
p_ni: 0.006773103
Score: 0.371
Data Source: BioPlex,STRINGDB
ZNF2
Family: TF
Novelty: 0.01062543
p_int: 0.99252828
p_ni: 0.00747172
Score: 0.183
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (4)
Processes (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
vascular endothelial growth factor measurement | 3 | 5 | 5 | 98.2 | |||||
hemoglobin measurement | 3 | 3 | 3 | 92.3 | |||||
hematocrit | 3 | 2 | 3 | 89.5 | |||||
low density lipoprotein cholesterol measurement | 6 | 1 | 6 | 75.9 | |||||
platelet count | 1 | 1 | 1 | 74.6 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
vascular endothelial growth factor measurement | 5 | 98.2 | |||||
hemoglobin measurement | 3 | 92.3 | |||||
hematocrit | 3 | 89.5 | |||||
low density lipoprotein cholesterol measurement | 6 | 75.9 | |||||
platelet count | 1 | 74.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (17)
1 – 5 of 17
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | pumilio RNA binding family member 3 | VGNC:4841 | 464968 | |||||
Macaque | pumilio RNA binding family member 3 | 696063 | ||||||
Mouse | MGI:106253 | 52874 | ||||||
Rat | RGD:1308750 | 294066 | ||||||
Dog | pumilio RNA binding family member 3 | VGNC:45208 | 476337 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | pumilio RNA binding family member 3 | |||||
Macaque | pumilio RNA binding family member 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | pumilio RNA binding family member 3 | |||||
Publication Statistics
PubMed Score 48.14
PubMed score by year
PubTator Score 2622.62
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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