Tbio PUM3 Pumilio homolog 3

Protein Summary

Description

Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity).

Uniprot Accession IDs

• Q15397
• A8K804
• Q547G7
• Q5SZY9
• Q6IB47
• Q96B27
• Q96L78
• Q96L79
• Q96L80

Gene Name

• PUM3

Ensembl ID

• ENST00000397885
• ENSP00000380982
• ENSG00000080608

Symbol

• cPERP-C
• KIAA0020
• PUF-A
• XTP5
• PEN
• HA-8
• PUF6
• XTP5
• PUF-A
• HLA-HA8
• KIAA0020

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.72   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 105   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.72   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0