Protein Summary
Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target ...more
- ENST00000338086
- ENSP00000338173
- ENSG00000055917
- ENST00000361078
- ENSP00000354370
- ENST00000403432
- ENSP00000385992
- KIAA0235
- PUMH2
- PUMH2
- PUML2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 0.97 | ||
ligand (protein) perturbation | 0.83 | ||
microRNA | 0.8 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.14 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 403 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.14 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 403 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (128)
LARP4B
Novelty: 0.11363794
p_int: 0.99999407
p_ni: 0.00000593
Score: 0.15
Data Source: BioPlex,STRINGDB
CLASRP
Novelty: 0.00582947
p_int: 0.999972005
p_ni: 0.000027793
p_wrong: 2.03e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
ELAVL2
Novelty: 0.00370708
p_int: 0.999971777
p_ni: 0.000028053
p_wrong: 1.7e-7
Score: 0.711
Data Source: BioPlex,STRINGDB
RBFOX2
Novelty: 0.00856339
p_int: 0.999932096
p_ni: 0.000067891
p_wrong: 1.3e-8
Score: 0.673
Data Source: BioPlex,STRINGDB
CELF5
Novelty: 0.04733002
p_int: 0.999802818
p_ni: 0.00019718
p_wrong: 2e-9
Score: 0.606
Data Source: BioPlex,STRINGDB
STRBP
Novelty: 0.00919158
p_int: 0.99944378
p_ni: 0.000555369
p_wrong: 8.51e-7
Score: 0.727
Data Source: BioPlex,STRINGDB
ILF2
Novelty: 0.01598188
p_int: 0.999303954
p_ni: 0.000694887
p_wrong: 0.000001159
Score: 0.686
Data Source: BioPlex,STRINGDB
CDX1
Family: TF
Novelty: 0.00815821
p_int: 0.998949936
p_ni: 0.001049746
p_wrong: 3.18e-7
Score: 0.399
Data Source: BioPlex,STRINGDB
LITAF
Family: TF
Novelty: 0.0097203
p_int: 0.998076275
p_ni: 0.000950164
p_wrong: 0.000973561
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Neddylation | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Metabolism of proteins | ||||
Neddylation | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (3)
Components (4)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 3 | 6 | 87.6 | |||||
apolipoprotein A 1 measurement | 1 | 2 | 2 | 83.7 | |||||
total cholesterol measurement | 2 | 4 | 6 | 82.2 | |||||
testosterone measurement | 3 | 2 | 3 | 82 | |||||
low density lipoprotein cholesterol measurement | 2 | 3 | 3 | 81.4 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 87.6 | |||||
apolipoprotein A 1 measurement | 2 | 83.7 | |||||
total cholesterol measurement | 6 | 82.2 | |||||
testosterone measurement | 3 | 82 | |||||
low density lipoprotein cholesterol measurement | 3 | 81.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | pumilio RNA binding family member 2 | VGNC:6396 | 459053 | |||||
Macaque | pumilio RNA binding family member 2 | 701782 | ||||||
Mouse | MGI:1931751 | 80913 | ||||||
Rat | RGD:1311024 | 298874 | ||||||
Dog | pumilio RNA binding family member 2 | VGNC:45207 | 607618 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | pumilio RNA binding family member 2 | |||||
Macaque | pumilio RNA binding family member 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | pumilio RNA binding family member 2 | |||||
Publication Statistics
PubMed Score 63.14
PubMed score by year
PubTator Score 29.27
PubTator score by year
Related Publications
Text Mined References (41)
GeneRif Annotations (22)
Items per page:
0 of 0
PMID | Year | Title |
---|