Tbio PUM2 Pumilio homolog 2

Protein Summary

Description

Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233). This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• Q8TB72
• B3KSL0
• B4E2B6
• D6W527
• O00234
• Q53TV7
• Q8WY43
• Q9HAN2
• Pumilio-2

Gene Name

• PUM2

Ensembl ID

• ENST00000338086
• ENSP00000338173
• ENSG00000055917
• ENST00000361078
• ENSP00000354370
• ENST00000403432
• ENSP00000385992

Symbol

• KIAA0235
• PUMH2
• PUMH2
• PUML2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.97
ligand (protein) perturbation	0.83
microRNA	0.8
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Pumilio Homolog 2

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Pumilio Homolog 2

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Pumilio Homolog 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.14   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 403   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.14   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (128)

Explore Interacting Targets

1 – 10 of 128

• See Interactions on String-DB

LARP4B

Tbio

Novelty:  0.11363794

p_int:  0.99999407

p_ni:  0.00000593

Score:  0.15

Data Source:  BioPlex,STRINGDB

CLASRP

Tbio

Novelty:  0.00582947

p_int:  0.999972005

p_ni:  0.000027793

p_wrong:  2.03e-7

Score:  0.188

Data Source:  BioPlex,STRINGDB

ELAVL2

Tbio

Novelty:  0.00370708

p_int:  0.999971777

p_ni:  0.000028053

p_wrong:  1.7e-7

Score:  0.711

Data Source:  BioPlex,STRINGDB

RBFOX2

Tbio

Novelty:  0.00856339

p_int:  0.999932096

p_ni:  0.000067891

p_wrong:  1.3e-8

Score:  0.673

Data Source:  BioPlex,STRINGDB

CELF5

Tbio

Novelty:  0.04733002

p_int:  0.999802818

p_ni:  0.00019718

p_wrong:  2e-9

Score:  0.606

Data Source:  BioPlex,STRINGDB

DAZ2

Tbio

p_int:  0.999671962

p_ni:  0.00032361

p_wrong:  0.000004428

Data Source:  BioPlex

STRBP

Tbio

Novelty:  0.00919158

p_int:  0.99944378

p_ni:  0.000555369

p_wrong:  8.51e-7

Score:  0.727

Data Source:  BioPlex,STRINGDB

ILF2

Tbio

Novelty:  0.01598188

p_int:  0.999303954

p_ni:  0.000694887

p_wrong:  0.000001159

Score:  0.686

Data Source:  BioPlex,STRINGDB

CDX1

Tbio

Family:  TF

Novelty:  0.00815821

p_int:  0.998949936

p_ni:  0.001049746

p_wrong:  3.18e-7

Score:  0.399

Data Source:  BioPlex,STRINGDB

LITAF

Tbio

Family:  TF

Novelty:  0.0097203

p_int:  0.998076275

p_ni:  0.000950164

p_wrong:  0.000973561

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Neddylation	234 targets	R-HSA-8951664
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Neddylation	234 targets	R-HSA-8951664
Post-translational protein modification	1450 targets	R-HSA-597592

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (3)

Components (4)

Processes (9)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
miRNA binding	Inferred from Direct Assay (IDA)	UniProtKB
mRNA 3'-UTR binding	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (14)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6	3	6		87.6
apolipoprotein A 1 measurement	EFO_0004614	1	2	2		83.7
total cholesterol measurement	EFO_0004574	2	4	6		82.2
testosterone measurement	EFO_0004908	3	2	3		82
low density lipoprotein cholesterol measurement	EFO_0004611	2	3	3		81.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6		87.6
apolipoprotein A 1 measurement	EFO_0004614	2		83.7
total cholesterol measurement	EFO_0004574	6		82.2
testosterone measurement	EFO_0004908	3		82
low density lipoprotein cholesterol measurement	EFO_0004611	3		81.4

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Methylation
Phosphoprotein
Polymorphism
Reference proteome
Repeat
RNA-binding

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
apolipoprotein B measurement
balding measurement
BMI-adjusted hip circumference
body mass index
high density lipoprotein cholesterol measurement
low density lipoprotein cholesterol measurement
plasminogen activator inhibitor 1 measurement
serum albumin measurement
serum urea measurement

MGI Phenotype Find Similar Targets

No Header	No Header
endocrine/exocrine gland phenotype
mortality/aging
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	pumilio RNA binding family member 2	VGNC:6396	459053
Macaque	pumilio RNA binding family member 2		701782
Mouse	pumilio RNA-binding family member 2	MGI:1931751	80913
Rat	pumilio RNA-binding family member 2	RGD:1311024	298874
Dog	pumilio RNA binding family member 2	VGNC:45207	607618

Species	Name	OMA	EggNOG	Inparanoid
Chimp	pumilio RNA binding family member 2
Macaque	pumilio RNA binding family member 2
Mouse	pumilio RNA-binding family member 2
Rat	pumilio RNA-binding family member 2
Dog	pumilio RNA binding family member 2

Publication Statistics

PubMed Score 63.14

PubMed score by year

Reset Zoom

PubTator Score 29.27

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (41)

GeneRif Annotations (22)

Items per page:

10

0 of 0

PMID	Year	Title