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Tbio
PUM2
Pumilio homolog 2

Protein Summary
Description
Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338086
  • ENSP00000338173
  • ENSG00000055917
  • ENST00000361078
  • ENSP00000354370
  • ENST00000403432
  • ENSP00000385992

Symbol
  • KIAA0235
  • PUMH2
  • PUMH2
  • PUML2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.97
ligand (protein) perturbation
0.83
microRNA
0.8
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.14   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.14   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.99999407
p_ni:  0.00000593
Score:  0.15
Data Source:  BioPlex,STRINGDB
CLASRP
Tbio
Novelty:  0.00582947
p_int:  0.999972005
p_ni:  0.000027793
p_wrong:  2.03e-7
Score:  0.188
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.999971777
p_ni:  0.000028053
p_wrong:  1.7e-7
Score:  0.711
Data Source:  BioPlex,STRINGDB
RBFOX2
Tbio
Novelty:  0.00856339
p_int:  0.999932096
p_ni:  0.000067891
p_wrong:  1.3e-8
Score:  0.673
Data Source:  BioPlex,STRINGDB
CELF5
Tbio
Novelty:  0.04733002
p_int:  0.999802818
p_ni:  0.00019718
p_wrong:  2e-9
Score:  0.606
Data Source:  BioPlex,STRINGDB
DAZ2
Tbio
p_int:  0.999671962
p_ni:  0.00032361
p_wrong:  0.000004428
Data Source:  BioPlex
STRBP
Tbio
Novelty:  0.00919158
p_int:  0.99944378
p_ni:  0.000555369
p_wrong:  8.51e-7
Score:  0.727
Data Source:  BioPlex,STRINGDB
ILF2
Tbio
Novelty:  0.01598188
p_int:  0.999303954
p_ni:  0.000694887
p_wrong:  0.000001159
Score:  0.686
Data Source:  BioPlex,STRINGDB
CDX1
Tbio
Family:  TF
Novelty:  0.00815821
p_int:  0.998949936
p_ni:  0.001049746
p_wrong:  3.18e-7
Score:  0.399
Data Source:  BioPlex,STRINGDB
LITAF
Tbio
Family:  TF
Novelty:  0.0097203
p_int:  0.998076275
p_ni:  0.000950164
p_wrong:  0.000973561
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
87.6
apolipoprotein A 1 measurement
1
2
2
83.7
total cholesterol measurement
2
4
6
82.2
testosterone measurement
3
2
3
82
low density lipoprotein cholesterol measurement
2
3
3
81.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
87.6
apolipoprotein A 1 measurement
2
83.7
total cholesterol measurement
6
82.2
testosterone measurement
3
82
low density lipoprotein cholesterol measurement
3
81.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pumilio RNA binding family member 2
VGNC:6396
459053
Macaque
pumilio RNA binding family member 2
701782
Mouse
MGI:1931751
80913
Rat
RGD:1311024
298874
Dog
pumilio RNA binding family member 2
VGNC:45207
607618
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pumilio RNA binding family member 2
Macaque
pumilio RNA binding family member 2
Mouse
Rat
Dog
pumilio RNA binding family member 2
Publication Statistics
PubMed Score 63.14
PubMed score by year
PubTator Score 29.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title