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Tbio
PUF60
Poly(U)-binding-splicing factor PUF60

Protein Summary
Description
DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313352
  • ENSP00000322016
  • ENSG00000179950
  • ENST00000349157
  • ENSP00000322036
  • ENST00000453551
  • ENSP00000402953
  • ENST00000456095
  • ENSP00000395417
  • ENST00000526683
  • ENSP00000434359
  • ENST00000527197
  • ENSP00000431960
  • ENST00000612237
  • ENSP00000478495
  • ENSG00000274081
  • ENST00000620341
  • ENSP00000484860
  • ENST00000620953
  • ENSP00000478209
  • ENST00000632444
  • ENSP00000487945
  • ENST00000633206
  • ENSP00000487930

Symbol
  • FIR
  • ROBPI
  • SIAHBP1
  • FIR
  • VRJS
  • RoBPI
  • SIAHBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
kinase perturbation
1
co-expressed gene
0.99
transcription factor binding site profile
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.41   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 413   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.41   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 413   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (280)
SREK1
Tbio
Novelty:  0.19228162
p_int:  0.999999966
p_ni:  3.4e-8
Score:  0.928
Data Source:  BioPlex,STRINGDB
SRSF11
Tbio
Novelty:  0.17035604
p_int:  0.999998566
p_ni:  0.000001434
p_wrong:  1e-9
Score:  0.987
Data Source:  BioPlex,STRINGDB
TRMT1
Tbio
Family:  Enzyme
Novelty:  0.01795504
p_int:  0.999935242
p_ni:  0.000064758
Score:  0.176
Data Source:  BioPlex,STRINGDB
PIR
Tchem
Novelty:  0.00327695
p_int:  0.999496984
p_ni:  0.00050035
p_wrong:  0.000002666
Data Source:  BioPlex
TROVE2
Tbio
Novelty:  0.00306038
p_int:  0.995427416
p_ni:  0.004572584
Score:  0.567
Data Source:  BioPlex,STRINGDB
SRPK2
Tchem
Family:  Kinase
Novelty:  0.03217228
p_int:  0.949860248
p_ni:  0.050139752
Data Source:  BioPlex
SSB
Tbio
Novelty:  0.00230478
p_int:  0.940072443
p_ni:  0.059927557
Score:  0.341
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.929770594
p_ni:  0.070229404
p_wrong:  2e-9
Score:  0.264
Data Source:  BioPlex,STRINGDB
SRPK1
Tchem
Family:  Kinase
Novelty:  0.01066655
p_int:  0.902089832
p_ni:  0.097910167
Score:  0.234
Data Source:  BioPlex,STRINGDB
SF3A2
Tbio
Novelty:  0.03658692
Score:  0.996
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
1
2
86.7
mean platelet volume
2
1
2
85.4
platelet crit
1
1
1
83.6
red blood cell density measurement
1
1
1
58.4
diastolic blood pressure
2
2
2
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
86.7
mean platelet volume
2
85.4
platelet crit
1
83.6
red blood cell density measurement
1
58.4
diastolic blood pressure
2
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(U) binding splicing factor 60
VGNC:13238
107976468
Macaque
poly(U) binding splicing factor 60
699008
Mouse
MGI:1915209
67959
Rat
RGD:621674
84401
Dog
poly(U) binding splicing factor 60
VGNC:51779
607245
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(U) binding splicing factor 60
Macaque
poly(U) binding splicing factor 60
Mouse
Rat
Dog
poly(U) binding splicing factor 60
Publication Statistics
PubMed Score 41.41
PubMed score by year
PubTator Score 34.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title