Tbio PTX3 Pentraxin-related protein PTX3

Protein Summary

Description

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]

Uniprot Accession IDs

• P26022
• B2R6T6
• Q38M82

Gene Name

• PTX3

Ensembl ID

• ENST00000295927
• ENSP00000295927
• ENSG00000163661

Symbol

• TNFAIP5
• TSG14
• TSG-14
• TNFAIP5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
biological term	0.99
gene perturbation	0.98
PubMedID	0.96
small molecule perturbation	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 889.05   (req: < 5)

Gene RIFs: 309   (req: <= 3)

Antibodies: 420   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 889.05   (req: >= 5)

Gene RIFs: 309   (req: > 3)

Antibodies: 420   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (149)

Explore Interacting Targets

1 – 10 of 149

• See Interactions on String-DB

CYB5D2

Tbio

Novelty:  0.23122479

p_int:  0.999999547

p_ni:  4.53e-7

Score:  0.188

Data Source:  BioPlex,STRINGDB

ZNF224

Tbio

Family:  TF

Novelty:  0.05381083

p_int:  0.999988437

p_ni:  0.00001137

p_wrong:  1.93e-7

Score:  0.197

Data Source:  BioPlex,STRINGDB

COLEC10

Tbio

Novelty:  0.02593638

p_int:  0.9999762

p_ni:  0.000023799

p_wrong:  1e-9

Score:  0.293

Data Source:  BioPlex,STRINGDB

A2M

Tbio

Novelty:  0.00070446

p_int:  0.99982907

p_ni:  0.000142432

p_wrong:  0.000028498

Score:  0.215

Data Source:  BioPlex,STRINGDB

OR5C1

Tdark

Family:  oGPCR

Novelty:  1.6529517

p_int:  0.998419118

p_ni:  0.001580881

Data Source:  BioPlex

TRMT10B

Tdark

Family:  Enzyme

Novelty:  0.61950381

p_int:  0.997227089

p_ni:  0.000978155

p_wrong:  0.001794756

Score:  0.181

Data Source:  BioPlex,STRINGDB

TNFAIP6

Tbio

Novelty:  0.0046811

Score:  0.988

Data Source:  STRINGDB

CFP

Tbio

Novelty:  0.00063251

Score:  0.949

Data Source:  STRINGDB

MMP9

Tchem

Family:  Enzyme

Novelty:  0.00008645

Score:  0.939

Data Source:  STRINGDB

CXCL1

Tbio

Novelty:  0.00059123

Score:  0.938

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (3)

WikiPathways (2)

Immune System (R-HSA-168256)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695

Name	Explore in Pharos	Explore in Source
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Neutrophil degranulation	543 targets	R-HSA-6798695

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (23)

Functions (4)

Components (5)

Processes (14)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
complement component C1q binding	Inferred from Direct Assay (IDA)	BHF-UCL
virion binding	Inferred from Direct Assay (IDA)	BHF-UCL
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
(1->3)-beta-D-glucan binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (1)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
pentraxin-related protein PTX3 measurement	EFO_0010923	1	2	2		76.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
pentraxin-related protein PTX3 measurement	EFO_0010923	2		76.2

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UniProt Keyword Find Similar Targets

No Header	No Header
Coiled coil
Complete proteome
Disulfide bond
Glycoprotein
Polymorphism
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
pentraxin-related protein PTX3 measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
immune system phenotype
reproductive system phenotype
respiratory system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	pentraxin 3	VGNC:2527	460807
Mouse	pentraxin related gene	MGI:104641	19288
Rat	pentraxin 3	RGD:1593476	689388
Dog	pentraxin 3	VGNC:45204	100685178
Cow	pentraxin 3	VGNC:33566	541148

Species	Name	OMA	EggNOG	Inparanoid
Chimp	pentraxin 3
Mouse	pentraxin related gene
Rat	pentraxin 3
Dog	pentraxin 3
Cow	pentraxin 3

Publication Statistics

PubMed Score 889.05

PubMed score by year

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PubTator Score 654.75

PubTator score by year

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Related Publications

Text Mined References (332)

GeneRif Annotations (309)

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PMID	Year	Title