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Tbio
PTTG1IP
Pituitary tumor-transforming gene 1 protein-interacting protein

Protein Summary
Description
May facilitate PTTG1 nuclear translocation. This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330938
  • ENSP00000328325
  • ENSG00000183255

Symbol
  • C21orf1
  • C21orf3
  • PBF
  • C21orf1
  • C21orf3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.97
transcription factor perturbation
0.96
transcription factor binding site profile
0.85
virus perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.32   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.32   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
STX7
Tbio
Novelty:  0.03109969
p_int:  0.948890152
p_ni:  4.17e-7
p_wrong:  0.05110943
Score:  0.225
Data Source:  BioPlex,STRINGDB
PTTG1
Tbio
Novelty:  0.00304349
Score:  0.807
Data Source:  STRINGDB
CDKL5
Tchem
Family:  Kinase
Novelty:  0.00444062
Score:  0.661
Data Source:  STRINGDB
JAM2
Tbio
Novelty:  0.02059056
Score:  0.626
Data Source:  STRINGDB
PKNOX1
Tbio
Family:  TF
Novelty:  0.01063674
Score:  0.62
Data Source:  STRINGDB
WDR4
Tbio
Family:  Enzyme
Novelty:  0.06887397
Score:  0.544
Data Source:  STRINGDB
NDUFV3
Tclin
Family:  Enzyme
Novelty:  0.15352039
Score:  0.535
Data Source:  STRINGDB
SYNJ1
Tchem
Novelty:  0.01030746
Score:  0.528
Data Source:  STRINGDB
U2AF1L4
Tbio
Novelty:  0.01735641
Score:  0.522
Data Source:  STRINGDB
AKAP2
Tbio
Family:  Enzyme
Novelty:  0.06414433
Score:  0.517
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
MGI
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
3
6
91.5
high density lipoprotein cholesterol measurement
11
2
11
89.7
red blood cell distribution width
3
2
3
86.1
heel bone mineral density
3
2
3
85.8
blood protein measurement
2
2
3
76.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
6
91.5
high density lipoprotein cholesterol measurement
11
89.7
red blood cell distribution width
3
86.1
heel bone mineral density
3
85.8
blood protein measurement
3
76.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PTTG1 interacting protein
458606
Macaque
PTTG1 interacting protein
722061
Mouse
MGI:2652132
108705
Rat
RGD:1305983
365548
Dog
pituitary tumor-transforming gene 1 protein-interacting protein-like
100855485
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PTTG1 interacting protein
Macaque
PTTG1 interacting protein
Mouse
Rat
Dog
pituitary tumor-transforming gene 1 protein-interacting protein-like
Publication Statistics
PubMed Score 12.32
PubMed score by year
PubTator Score 112.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title