You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PTPRZ1
Receptor-type tyrosine-protein phosphatase zeta

Protein Summary
Description
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity). This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393386
  • ENSP00000377047
  • ENSG00000106278
  • ENST00000449182
  • ENSP00000410000

Symbol
  • HTPZP2
  • PTPRZ
  • PTPRZ2
  • PTPZ
  • PTPZ
  • HPTPZ
  • PTP18
  • PTPRZ
  • RPTPB
  • HPTPzeta
  • PTP-ZETA
  • RPTPbeta
  • phosphacan
  • R-PTP-zeta-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
protein domain
0.92
gene perturbation
0.73
molecular function
0.6
biological term
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.08   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.08   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (112)
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.887722856
p_ni:  6e-9
p_wrong:  0.112277138
Score:  0.232
Data Source:  BioPlex,STRINGDB
CNTN1
Tbio
Novelty:  0.00741212
Score:  0.989
Data Source:  STRINGDB
IL34
Tbio
Novelty:  0.00838631
Score:  0.932
Data Source:  Reactome,STRINGDB
PTN
Tchem
Novelty:  0.00129524
Score:  0.922
Data Source:  STRINGDB
NCAN
Tbio
Novelty:  0.00401824
Score:  0.918
Data Source:  STRINGDB
BCAN
Tbio
Novelty:  0.00737982
Score:  0.851
Data Source:  STRINGDB
ALK
Tclin
Family:  Kinase
Novelty:  0.00022375
Score:  0.829
Data Source:  STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.761
Data Source:  STRINGDB
CNTN2
Tbio
Novelty:  0.00213251
Score:  0.753
Data Source:  STRINGDB
VCAN
Tbio
Novelty:  0.00110986
Score:  0.744
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Other interleukin signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Other interleukin signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
66.3
high density lipoprotein cholesterol measurement
2
1
3
9.2
smoking status measurement
1
1
2
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
66.3
high density lipoprotein cholesterol measurement
3
9.2
smoking status measurement
2
6.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type Z1
VGNC:8740
463681
Macaque
protein tyrosine phosphatase, receptor type Z1
574174
Mouse
MGI:97816
19283
Rat
RGD:3455
25613
Dog
protein tyrosine phosphatase, receptor type Z1
VGNC:54793
482428
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type Z1
Macaque
protein tyrosine phosphatase, receptor type Z1
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type Z1
Publication Statistics
PubMed Score 203.08
PubMed score by year
PubTator Score 86.96
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title