Tchem PTPRZ1 Receptor-type tyrosine-protein phosphatase zeta

Protein Summary

Description

Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity). This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• P23471
• A4D0W5
• C9JFM0
• O76043
• Q9UDR6
• R-PTP-zeta

Gene Name

• PTPRZ1

Ensembl ID

• ENST00000393386
• ENSP00000377047
• ENSG00000106278
• ENST00000449182
• ENSP00000410000

Symbol

• HTPZP2
• PTPRZ
• PTPRZ2
• PTPZ
• PTPZ
• HPTPZ
• PTP18
• PTPRZ
• RPTPB
• HPTPzeta
• PTP-ZETA
• RPTPbeta
• phosphacan
• R-PTP-zeta-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.98
protein domain	0.92
gene perturbation	0.73
molecular function	0.6
biological term	0.58

Protein Classes

PANTHER Classes

Protein / Receptor / Receptor-type Tyrosine-protein Phosphatase Zeta

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Receptor-type Tyrosine-protein Phosphatase Zeta

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Receptor-type Tyrosine-protein Phosphatase Zeta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.93   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 177   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.93   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0