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Tbio
PTPRU
Receptor-type tyrosine-protein phosphatase U

Protein Summary
Description
Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The exp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345512
  • ENSP00000334941
  • ENSG00000060656
  • ENST00000373779
  • ENSP00000362884
  • ENST00000428026
  • ENSP00000392332
  • ENST00000460170
  • ENSP00000432906

Symbol
  • FMI
  • PCP2
  • PTPRO
  • FMI
  • PTP
  • PCP-2
  • PTP-J
  • PTPRO
  • PTPU2
  • PTP-PI
  • PTP-RO
  • PTPPSI
  • hPTP-J
  • R-PTP-U
  • R-PTP-PSI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
PubMedID
0.87
transcription factor binding site profile
0.87
kinase perturbation
0.76
cell type or tissue
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.6   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.6   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.999688206
p_ni:  0.000311793
Score:  0.197
Data Source:  BioPlex,STRINGDB
GOLIM4
Tbio
Novelty:  0.01923513
p_int:  0.999180459
p_ni:  0.00081954
p_wrong:  1e-9
Data Source:  BioPlex
AAMP
Tbio
Novelty:  0.0160792
p_int:  0.995518575
p_ni:  0.004481425
Score:  0.295
Data Source:  BioPlex,STRINGDB
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.96967027
p_ni:  0.03032973
Score:  0.278
Data Source:  BioPlex,STRINGDB
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.952989673
p_ni:  0.047010327
Data Source:  BioPlex
SGCA
Tbio
Novelty:  0.00442268
p_int:  0.909864635
p_ni:  0.090135365
Score:  0.295
Data Source:  BioPlex,STRINGDB
TMEM98
Tbio
Novelty:  0.10281593
p_int:  0.906951564
p_ni:  0.093048436
Data Source:  BioPlex
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.902825397
p_ni:  0.097174603
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.89318395
p_ni:  0.10681605
Data Source:  BioPlex
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.88953754
p_ni:  0.110462456
p_wrong:  4e-9
Score:  0.264
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (115)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Receptor Tyrosine Kinases
Reactome
Signaling by SCF-KIT
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Receptor Tyrosine Kinases
Signaling by SCF-KIT
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
1
2
62.1
hemoglobin measurement
2
1
2
59.9
diastolic blood pressure
1
1
1
50.6
high density lipoprotein cholesterol measurement
1
1
1
42.3
apolipoprotein A 1 measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
62.1
hemoglobin measurement
2
59.9
diastolic blood pressure
1
50.6
high density lipoprotein cholesterol measurement
1
42.3
apolipoprotein A 1 measurement
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type U
VGNC:9890
456692
Macaque
protein tyrosine phosphatase, receptor type U
720393
Mouse
MGI:1321151
19273
Rat
RGD:620782
116680
Dog
protein tyrosine phosphatase, receptor type U
VGNC:45200
487328
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type U
Macaque
protein tyrosine phosphatase, receptor type U
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type U
Publication Statistics
PubMed Score 111.60
PubMed score by year
PubTator Score 328.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title