You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PTPRU
Receptor-type tyrosine-protein phosphatase U

Protein Summary
Description
Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The exp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345512
  • ENSP00000334941
  • ENSG00000060656
  • ENST00000373779
  • ENSP00000362884
  • ENST00000428026
  • ENSP00000392332
  • ENST00000460170
  • ENSP00000432906

Symbol
  • FMI
  • PCP2
  • PTPRO
  • FMI
  • PTP
  • PCP-2
  • PTP-J
  • PTPRO
  • PTPU2
  • PTP-PI
  • PTP-RO
  • PTPPSI
  • hPTP-J
  • R-PTP-U
  • R-PTP-PSI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
PubMedID
0.87
transcription factor binding site profile
0.87
kinase perturbation
0.76
cell type or tissue
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.97   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.97   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0