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Tchem
PTPRS
Receptor-type tyrosine-protein phosphatase S

Protein Summary
Description
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000587303
  • ENSP00000467537
  • ENSG00000105426
  • ENST00000588012
  • ENSP00000465443
  • ENST00000592099
  • ENSP00000467398

Symbol
  • R-PTP-S
  • PTPSIGMA
  • R-PTP-sigma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
small molecule perturbation
0.86
transcription factor binding site profile
0.8
kinase perturbation
0.71
transcription factor
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.81   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.81   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (111)
NTRK3
Tclin
Family:  Kinase
Novelty:  0.00177321
p_int:  0.999968839
p_ni:  0.000031159
p_wrong:  2e-9
Score:  0.959
Data Source:  BioPlex,Reactome,STRINGDB
PCDH12
Tbio
Novelty:  0.06268895
p_int:  0.999941342
p_ni:  0.000058657
Score:  0.22
Data Source:  BioPlex,STRINGDB
CLU
Tbio
Novelty:  0.00054776
p_int:  0.999888761
p_ni:  0.000111239
Score:  0.17
Data Source:  BioPlex,STRINGDB
LRRIQ1
Tdark
Novelty:  1.8251367
p_int:  0.999157465
p_ni:  0.000842535
Score:  0.274
Data Source:  BioPlex,STRINGDB
CEACAM21
Tdark
Novelty:  0.46116153
p_int:  0.998361023
p_ni:  0.001638977
Data Source:  BioPlex
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
p_int:  0.997711622
p_ni:  0.002288378
Data Source:  BioPlex
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.997708449
p_ni:  0.002291551
Score:  0.246
Data Source:  BioPlex,STRINGDB
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.996483422
p_ni:  0.003516578
Data Source:  BioPlex
FKBP9
Tbio
Family:  Enzyme
Novelty:  0.16472204
p_int:  0.996109287
p_ni:  0.003890713
Score:  0.164
Data Source:  BioPlex,STRINGDB
TNFSF8
Tbio
Novelty:  0.01292216
p_int:  0.992148244
p_ni:  0.007851755
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Receptor-type tyrosine-protein phosphatases
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Neuronal System
Protein-protein interactions at synapses
Receptor-type tyrosine-protein phosphatases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
74.3
insomnia measurement
1
1
0
1
50.6
IGF-1 measurement
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
74.3
insomnia measurement
0
1
50.6
IGF-1 measurement
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97815
19280
Rat
RGD:3452
25529
Dog
protein tyrosine phosphatase, receptor type S
VGNC:45198
485030
Cow
protein tyrosine phosphatase, receptor type S
VGNC:33558
537480
Pig
protein tyrosine phosphatase, receptor type S
106509452
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type S
Cow
protein tyrosine phosphatase, receptor type S
Pig
protein tyrosine phosphatase, receptor type S
Publication Statistics
PubMed Score 205.81
PubMed score by year
PubTator Score 33.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title