Tbio PTPRO Receptor-type tyrosine-protein phosphatase O

Protein Summary

Description

Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity). This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• Q16827
• A0AV39
• Q13101
• Q8IYG3
• Q9UBF0
• Q9UBT5
• R-PTP-O

Gene Name

• PTPRO

Ensembl ID

• ENST00000281171
• ENSP00000281171
• ENSG00000151490
• ENST00000348962
• ENSP00000343434
• ENST00000442921
• ENSP00000404188
• ENST00000445537
• ENSP00000393449
• ENST00000542557
• ENSP00000437571
• ENST00000543886
• ENSP00000444173
• ENST00000544244
• ENSP00000439234

Symbol

• GLEPP1
• PTPU2
• NPHS6
• PTPU2
• GLEPP1
• PTP-OC
• PTP-U2
• PTPROT
• R-PTP-O

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
biological process	0.87
protein domain	0.85
molecular function	0.73
cellular component	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.88   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.88   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0