Tbio PTPRM Receptor-type tyrosine-protein phosphatase mu

Protein Summary

Description

Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P28827
• A7MBN1
• D3DUH8
• J3QL11
• Protein-tyrosine phosphatase mu

Gene Name

• PTPRM

Ensembl ID

• ENST00000332175
• ENSP00000331418
• ENSG00000173482
• ENST00000580170
• ENSP00000463325

Symbol

• PTPRL1
• RPTPM
• RPTPU
• PTPRL1
• hR-PTPu
• R-PTP-MU

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
trait	1
PubMedID	0.96
disease perturbation	0.95
virus perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Receptor / Receptor-type Tyrosine-protein Phosphatase Mu

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Receptor-type Tyrosine-protein Phosphatase Mu

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Receptor-type Tyrosine-protein Phosphatase Mu

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.68   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 219   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.68   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0