PTPRD
Receptor-type tyrosine-protein phosphatase delta
Protein Summary
Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. ...more
- ENST00000355233
- ENSP00000347373
- ENSG00000153707
- ENST00000356435
- ENSP00000348812
- ENST00000381196
- ENSP00000370593
- ENST00000397606
- ENSP00000380731
- ENST00000397611
- ENSP00000380735
- ENST00000486161
- ENSP00000417093
- ENST00000540109
- ENSP00000438164
- ENST00000634556
- ENSP00000489063
- ENSG00000282932
- ENST00000634583
- ENSP00000489509
- ENST00000634608
- ENSP00000489257
- ENST00000635012
- ENSP00000489439
- ENST00000635279
- ENSP00000488982
- ENST00000635611
- ENSP00000489155
- ENST00000635613
- ENSP00000489038
- HPTP
- PTPD
- HPTPD
- HPTPDELTA
- RPTPDELTA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
protein domain | 0.99 | ||
PubMedID | 0.87 | ||
disease | 0.85 | ||
microRNA | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 137.42 (req: < 5)
Gene RIFs: 67 (req: <= 3)
Antibodies: 129 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 137.42 (req: >= 5)
Gene RIFs: 67 (req: > 3)
Antibodies: 129 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0