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Tchem
PTPRC
Receptor-type tyrosine-protein phosphatase C

Protein Summary
Description
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348564
  • ENSP00000306782
  • ENSG00000081237
  • ENST00000442510
  • ENSP00000411355
  • ENST00000573477
  • ENSP00000461074
  • ENSG00000262418
  • ENST00000573679
  • ENSP00000458322

Symbol
  • CD45
  • LCA
  • LY5
  • B220
  • CD45
  • L-CA
  • T200
  • CD45R
  • GP180
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
1
protein domain
0.97
gene perturbation
0.85
hub protein
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9320.88   (req: < 5)
Gene RIFs: 187   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9320.88   (req: >= 5)
Gene RIFs: 187   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 74
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 65
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0