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Tbio
PTPN23
Tyrosine-protein phosphatase non-receptor type 23

Protein Summary
Description
Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis. This gene encodes a member of the non-receptor type protein-tyrosine phosphatase family. The encoded protein may be involved in the regulation of small nuclear ribonucleo protein assembly and pre-mRNA splicing by modifying the survival motor neuron (SMN) complex. The encoded protein additionally plays a role in ciliogenesis and is part of endosomal sorting complex required for transport (ESCRT) pathways. This gene may serve a tumor suppressor function. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265562
  • ENSP00000265562
  • ENSG00000076201

Symbol
  • KIAA1471
  • HDPTP
  • HD-PTP
  • PTP-TD14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.89
interacting protein
0.84
transcription factor binding site profile
0.67
biological process
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.8   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.8   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (110)
GRAP2
Tbio
Novelty:  0.00503901
p_int:  0.999999991
p_ni:  7e-9
p_wrong:  2e-9
Score:  0.635
Data Source:  BioPlex,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999850555
p_ni:  0.000149436
p_wrong:  9e-9
Score:  0.786
Data Source:  BioPlex,STRINGDB
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.999621471
p_ni:  0.000366679
p_wrong:  0.00001185
Data Source:  BioPlex
VWA5A
Tbio
Novelty:  0.0802354
p_int:  0.998204227
p_ni:  0.001794617
p_wrong:  0.000001155
Score:  0.164
Data Source:  BioPlex,STRINGDB
CHMP4A
Tbio
Novelty:  0.01163844
Score:  0.991
Data Source:  STRINGDB
STAM2
Tbio
Novelty:  0.04440236
Score:  0.968
Data Source:  STRINGDB
CHMP4B
Tbio
Novelty:  0.01391352
Score:  0.963
Data Source:  STRINGDB
UBAP1
Tbio
Novelty:  0.02276845
Score:  0.962
Data Source:  STRINGDB
ZFYVE9
Tbio
Novelty:  0.00565862
Score:  0.946
Data Source:  STRINGDB
ZFYVE16
Tbio
Novelty:  0.10765234
Score:  0.929
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-37 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-37 signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
78.1
macrophage inflammatory protein 1b measurement
1
1
1
76.4
heel bone mineral density
1
1
1
29
triglyceride measurement
1
1
1
17.8
serum non-albumin protein measurement
1
1
1
13.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
78.1
macrophage inflammatory protein 1b measurement
1
76.4
heel bone mineral density
1
29
triglyceride measurement
1
17.8
serum non-albumin protein measurement
1
13.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 23
VGNC:10043
460333
Macaque
protein tyrosine phosphatase, non-receptor type 23
711601
Mouse
MGI:2144837
104831
Rat
RGD:619892
117552
Dog
protein tyrosine phosphatase, non-receptor type 23
609220
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 23
Macaque
protein tyrosine phosphatase, non-receptor type 23
Mouse
Rat
Dog
protein tyrosine phosphatase, non-receptor type 23
Publication Statistics
PubMed Score 36.80
PubMed score by year
PubTator Score 21.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title