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Tchem
PTPN2
Tyrosine-protein phosphatase non-receptor type 2

Protein Summary
Description
Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signali ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309660
  • ENSP00000311857
  • ENSG00000175354
  • ENST00000327283
  • ENSP00000320298
  • ENST00000353319
  • ENSP00000320546
  • ENST00000591115
  • ENSP00000466936

Symbol
  • PTPT
  • PTN2
  • PTPT
  • TCPTP
  • TC-PTP
  • TCELLPTP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
virus perturbation
1
disease perturbation
0.99
trait
0.93
transcription factor binding site profile
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.89   (req: < 5)
Gene RIFs: 90   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.89   (req: >= 5)
Gene RIFs: 90   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 173
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0