Tbio PTPN18 Tyrosine-protein phosphatase non-receptor type 18

Protein Summary

Description

Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Uniprot Accession IDs

• Q99952
• B4E1E6
• Q53P42

Gene Name

• PTPN18

Ensembl ID

• ENST00000175756
• ENSP00000175756
• ENSG00000072135
• ENST00000347849
• ENSP00000310092

Symbol

• BDP1
• BDP1
• PTP-HSCF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
disease perturbation	0.87
drug perturbation	0.87
kinase perturbation	0.84
histone modification site profile	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.37   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.37   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0