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Tbio
PTPN14
Tyrosine-protein phosphatase non-receptor type 14

Protein Summary
Description
Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366956
  • ENSP00000355923
  • ENSG00000152104

Symbol
  • PEZ
  • PTPD2
  • PEZ
  • PTP36
  • CATLPH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.93
transcription factor perturbation
0.88
interacting protein
0.77
trait
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.26   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.26   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
MAGI1
Tbio
Family:  Enzyme
Novelty:  0.06837323
p_int:  0.999999993
p_ni:  5e-9
p_wrong:  2e-9
Score:  0.399
Data Source:  BioPlex,STRINGDB
RHPN1
Tbio
Novelty:  0.05722992
p_int:  0.999999748
p_ni:  2.42e-7
p_wrong:  1e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
MAGI3
Tbio
Family:  Enzyme
Novelty:  0.03968945
p_int:  0.999998833
p_ni:  0.000001166
p_wrong:  1e-9
Score:  0.25
Data Source:  BioPlex,STRINGDB
YAP1
Tchem
Novelty:  0.00124225
p_int:  0.999995007
p_ni:  0.000004993
p_wrong:  1e-9
Score:  0.848
Data Source:  BioPlex,STRINGDB
STXBP4
Tbio
Novelty:  0.08831326
p_int:  0.99999327
p_ni:  0.00000673
Score:  0.183
Data Source:  BioPlex,STRINGDB
PDLIM7
Tbio
Novelty:  0.00544518
p_int:  0.99992544
p_ni:  0.00007456
Score:  0.246
Data Source:  BioPlex,STRINGDB
PHF20
Tbio
Family:  Epigenetic
Novelty:  0.01961423
p_int:  0.999905125
p_ni:  0.000094875
Score:  0.218
Data Source:  BioPlex,STRINGDB
JPH4
Tbio
Novelty:  0.07699598
p_int:  0.993759839
p_ni:  0.006240161
Data Source:  BioPlex
PARD6B
Tbio
Novelty:  0.08495161
p_int:  0.993313228
p_ni:  0.006686772
Score:  0.295
Data Source:  BioPlex,STRINGDB
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
p_int:  0.752324411
p_ni:  0.247675589
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-37 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-37 signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
1
2
69.2
balding measurement
1
1
1
53.3
smoking status measurement
1
1
1
51.7
birth weight
1
1
1
48.5
smoking initiation
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
69.2
balding measurement
1
53.3
smoking status measurement
1
51.7
birth weight
1
48.5
smoking initiation
1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 14
VGNC:14275
457730
Macaque
protein tyrosine phosphatase, non-receptor type 14
709191
Mouse
MGI:102467
19250
Rat
RGD:1307885
305064
Dog
protein tyrosine phosphatase, non-receptor type 14
VGNC:45171
490293
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, non-receptor type 14
Macaque
protein tyrosine phosphatase, non-receptor type 14
Mouse
Rat
Dog
protein tyrosine phosphatase, non-receptor type 14
Publication Statistics
PubMed Score 73.26
PubMed score by year
PubTator Score 51.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title