Tchem PTPMT1 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Protein Summary

Description

Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity (PubMed:24709986).

Uniprot Accession IDs

• Q8WUK0
• E9PAT8
• Q7Z557
• Q96CR2
• Q9BXV8

Gene Name

• PTPMT1

Ensembl ID

• ENST00000326656
• ENSP00000325882
• ENSG00000110536
• ENST00000326674
• ENSP00000325958
• ENST00000426530
• ENSP00000410272
• ENST00000643547
• ENSP00000494387
• ENSG00000285206
• ENST00000646905
• ENSP00000495288
• ENST00000647378
• ENSP00000496417

Symbol

• MOSP
• PLIP
• MOSP
• PLIP
• DUSP23
• PNAS-129

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
transcription factor perturbation	0.8
protein domain	0.73
tissue sample	0.73
cellular component	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.59   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 160   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.59   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1