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Tchem
PTP4A2
Protein tyrosine phosphatase type IVA 2

Protein Summary
Description
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000457805
  • ENSP00000409260
  • ENSG00000184007
  • ENST00000602683
  • ENSP00000473490
  • ENST00000602725
  • ENSP00000473259
  • ENST00000647444
  • ENSP00000493688
  • ENST00000649841
  • ENSP00000497092

Symbol
  • PRL2
  • PTPCAAX2
  • HH13
  • OV-1
  • PRL2
  • HH7-2
  • PRL-2
  • PTP4A
  • HU-PP-1
  • PTPCAAX2
  • ptp-IV1a
  • ptp-IV1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
virus perturbation
1
transcription factor perturbation
0.96
transcription factor binding site profile
0.94


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.59   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.59   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (46)
PTP4A1
Tchem
Family:  Enzyme
Novelty:  0.02863007
p_int:  0.999999991
p_ni:  8e-9
Score:  0.725
Data Source:  BioPlex,STRINGDB
CNNM1
Tdark
Novelty:  0.11053515
p_int:  0.999999203
p_ni:  7.91e-7
p_wrong:  5e-9
Score:  0.789
Data Source:  BioPlex,STRINGDB
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.999788872
p_ni:  0.000211128
Score:  0.936
Data Source:  BioPlex,Reactome,STRINGDB
EFL1
Tbio
Novelty:  0.1323879
p_int:  0.999497363
p_ni:  0.000093726
p_wrong:  0.000408911
Score:  0.215
Data Source:  BioPlex,STRINGDB
CNNM4
Tbio
Novelty:  0.04199329
p_int:  0.997631252
p_ni:  0.002368748
Score:  0.853
Data Source:  BioPlex,STRINGDB
CNNM2
Tbio
Novelty:  0.03252541
p_int:  0.98390447
p_ni:  0.01609553
Score:  0.839
Data Source:  BioPlex,STRINGDB
FNTA
Tclin
Family:  Enzyme
Novelty:  0.03163169
p_int:  0.979674709
p_ni:  0.020208271
p_wrong:  0.00011702
Score:  0.176
Data Source:  BioPlex,STRINGDB
PCDHB5
Tdark
Novelty:  0.49458103
p_int:  0.96824698
p_ni:  0.03171686
p_wrong:  0.00003616
Score:  0.188
Data Source:  BioPlex,STRINGDB
FMN2
Tbio
Novelty:  0.02031944
p_int:  0.966225318
p_ni:  0.003023119
p_wrong:  0.030751563
Score:  0.169
Data Source:  BioPlex,STRINGDB
GPAA1
Tbio
Novelty:  0.01874575
p_int:  0.956921576
p_ni:  0.04298222
p_wrong:  0.000096204
Score:  0.168
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
RAB geranylgeranylation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
2
66.6
testosterone measurement
1
1
1
33.1
BMI-adjusted hip circumference
1
2
2
26.5
reticulocyte count
2
1
2
15.4
BMI-adjusted waist circumference
1
1
1
0
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
66.6
testosterone measurement
1
33.1
BMI-adjusted hip circumference
2
26.5
reticulocyte count
2
15.4
BMI-adjusted waist circumference
1
0
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1277117
19244
Rat
RGD:619786
85237
Dog
protein tyrosine phosphatase type IVA, member 2
VGNC:45162
609835
Horse
protein tyrosine phosphatase type IVA, member 2
VGNC:49526
100056044
Cow
protein tyrosine phosphatase type IVA, member 2
VGNC:33524
614435
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
protein tyrosine phosphatase type IVA, member 2
Horse
protein tyrosine phosphatase type IVA, member 2
Cow
protein tyrosine phosphatase type IVA, member 2
Publication Statistics
PubMed Score 124.59
PubMed score by year
PubTator Score 97.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title