You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PTP4A2
Protein tyrosine phosphatase type IVA 2

Protein Summary
Description
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000457805
  • ENSP00000409260
  • ENSG00000184007
  • ENST00000602683
  • ENSP00000473490
  • ENST00000602725
  • ENSP00000473259
  • ENST00000647444
  • ENSP00000493688
  • ENST00000649841
  • ENSP00000497092

Symbol
  • PRL2
  • PTPCAAX2
  • HH13
  • OV-1
  • PRL2
  • HH7-2
  • PRL-2
  • PTP4A
  • HU-PP-1
  • PTPCAAX2
  • ptp-IV1a
  • ptp-IV1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
virus perturbation
1
transcription factor perturbation
0.96
transcription factor binding site profile
0.94


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.81   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.81   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1