Tchem PTP4A1 Protein tyrosine phosphatase type IVA 1

Protein Summary

Description

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• Q93096
• B2R6C8
• O00648
• Q49A54

Gene Name

• PTP4A1

Ensembl ID

• ENST00000626021
• ENSP00000485687
• ENSG00000112245
• ENST00000648894
• ENSP00000497588

Symbol

• PRL1
• PTPCAAX1
• HH72
• PRL1
• PRL-1
• PTPCAAX1
• PTP(CAAX1)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
disease perturbation	0.98
transcription factor binding site profile	0.97
microRNA	0.93
interacting protein	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.36   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 268   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.36   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1