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Tchem
PTP4A1
Protein tyrosine phosphatase type IVA 1

Protein Summary
Description
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000626021
  • ENSP00000485687
  • ENSG00000112245
  • ENST00000648894
  • ENSP00000497588

Symbol
  • PRL1
  • PTPCAAX1
  • HH72
  • PRL1
  • PRL-1
  • PTPCAAX1
  • PTP(CAAX1)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.98
transcription factor binding site profile
0.97
microRNA
0.93
interacting protein
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.66   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.66   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (92)
PTP4A2
Tchem
Family:  Enzyme
Novelty:  0.0083639
p_int:  0.999999991
p_ni:  8e-9
Score:  0.725
Data Source:  BioPlex,STRINGDB
CNNM1
Tdark
Novelty:  0.11053515
p_int:  0.999999649
p_ni:  3.51e-7
Score:  0.791
Data Source:  BioPlex,STRINGDB
CNNM4
Tbio
Novelty:  0.04199329
p_int:  0.999623832
p_ni:  0.000376168
Score:  0.927
Data Source:  BioPlex,STRINGDB
CNNM2
Tbio
Novelty:  0.03252541
p_int:  0.999495999
p_ni:  0.000504001
Score:  0.982
Data Source:  BioPlex,STRINGDB
CLTCL1
Tbio
Novelty:  0.05667807
p_int:  0.998165768
p_ni:  0.001834232
Data Source:  BioPlex
ATE1
Tbio
Family:  Enzyme
Novelty:  0.01672896
p_int:  0.99614665
p_ni:  0.00385335
Data Source:  BioPlex
GINS2
Tbio
Novelty:  0.0078966
p_int:  0.992801548
p_ni:  0.001135689
p_wrong:  0.006062764
Data Source:  BioPlex
TRPM7
Tchem
Family:  IC
Novelty:  0.00265096
p_int:  0.991248573
p_ni:  0.004631809
p_wrong:  0.004119618
Data Source:  BioPlex
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.97314465
p_ni:  0.02685535
Score:  0.245
Data Source:  BioPlex,STRINGDB
CNNM3
Tbio
Novelty:  0.13988333
p_int:  0.964217049
p_ni:  0.035782951
Score:  0.914
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
40.7
testosterone measurement
1
1
1
38.2
1
1
1
14.2
1
1
1
14.2
1
1
1
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
40.7
testosterone measurement
1
38.2
1
14.2
1
14.2
1
0.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein tyrosine phosphatase type IVA, member 1
716195
Mouse
MGI:1277096
19243
Rat
RGD:61970
29463
Dog
protein tyrosine phosphatase type IVA, member 1
481863
Horse
protein tyrosine phosphatase type IVA, member 1
VGNC:22005
100057042
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein tyrosine phosphatase type IVA, member 1
Mouse
Rat
Dog
protein tyrosine phosphatase type IVA, member 1
Horse
protein tyrosine phosphatase type IVA, member 1
Publication Statistics
PubMed Score 41.66
PubMed score by year
PubTator Score 58.37
PubTator score by year
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Related Publications
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PMID
Year
Title