You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PTOV1
Prostate tumor-overexpressed gene 1 protein

Protein Summary
Description
May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391842
  • ENSP00000375717
  • ENSG00000104960
  • ENST00000599732
  • ENSP00000469128
  • ENST00000601675
  • ENSP00000472816

Symbol
  • ACID2
  • ACID2
  • PTOV-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
disease perturbation
0.83
cell type or tissue
0.73
transcription factor binding site profile
0.66
transcription factor
0.65


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.43   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.43   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
KLHDC2
Tbio
Novelty:  0.01485159
p_int:  0.988074522
p_ni:  0.011925478
Score:  0.549
Data Source:  BioPlex,STRINGDB
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.947058929
p_ni:  0.052941071
Score:  0.191
Data Source:  BioPlex,STRINGDB
C16orf71
Tdark
Novelty:  0.97826087
p_int:  0.88809778
p_ni:  0.11190222
Score:  0.729
Data Source:  BioPlex,STRINGDB
AFAP1L1
Tbio
Novelty:  0.2636613
p_int:  0.882261166
p_ni:  0.117738834
Data Source:  BioPlex
FLOT1
Tbio
Novelty:  0.00504569
Score:  0.877
Data Source:  STRINGDB
FLOT2
Tbio
Novelty:  0.00727325
Score:  0.808
Data Source:  STRINGDB
KMT2A
Tchem
Family:  Epigenetic
Novelty:  0.00192554
Score:  0.789
Data Source:  STRINGDB
MED6
Tbio
Family:  Enzyme
Novelty:  0.05215086
Score:  0.712
Data Source:  STRINGDB
SMIM12
Tdark
Novelty:  0.46683938
Score:  0.691
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.67
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
1
1
54.4
serum albumin measurement
1
1
1
50.6
mathematical ability
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
54.4
serum albumin measurement
1
50.6
mathematical ability
1
14.2
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostate tumor overexpressed 1
104003407
Macaque
prostate tumor overexpressed 1
719449
Mouse
MGI:1933946
84113
Rat
RGD:1306977
292888
Dog
prostate tumor overexpressed 1
VGNC:45161
612927
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostate tumor overexpressed 1
Macaque
prostate tumor overexpressed 1
Mouse
Rat
Dog
prostate tumor overexpressed 1
Publication Statistics
PubMed Score 30.43
PubMed score by year
PubTator Score 174.69
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title