Protein Summary
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777). The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
- ENST00000348225
- ENSP00000341170
- ENSG00000105894
- HBNF1
- NEGF1
- HARP
- HBBM
- HBNF
- HBGF8
- NEGF1
- OSF-1
- HB-GAM
- HBGF-8
- HBNF-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.96 | ||
small molecule perturbation | 0.8 | ||
transcription factor perturbation | 0.8 | ||
gene perturbation | 0.76 | ||
biological term | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 892.4 (req: < 5)
Gene RIFs: 98 (req: <= 3)
Antibodies: 517 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 892.4 (req: >= 5)
Gene RIFs: 98 (req: > 3)
Antibodies: 517 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 48
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (72)
Nearest Tclin Targets
Pathways (1)
PathwayCommons (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: pid | Syndecan-3-mediated signaling events | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Syndecan-3-mediated signaling events | ||||
Viral Interactions (0)
Gene Ontology Terms (59)
Functions (8)
Components (11)
Processes (40)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
11 | 6 | 3 | 1.1 | 87.9 | |||||
self reported educational attainment | 4 | 3 | 4 | 81.5 | |||||
risk-taking behaviour | 2 | 2 | 2 | 71.6 | |||||
1 | 1 | 0 | 1.1 | 38.2 | |||||
neuroticism measurement | 1 | 1 | 0 | 5.8 | 28.1 | ||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
3 | 1.1 | 87.9 | |||||
self reported educational attainment | 4 | 81.5 | |||||
risk-taking behaviour | 2 | 71.6 | |||||
0 | 1.1 | 38.2 | |||||
neuroticism measurement | 0 | 5.8 | 28.1 | ||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | pleiotrophin | VGNC:4483 | 463759 | |||||
Macaque | pleiotrophin | 709496 | ||||||
Mouse | MGI:97804 | 19242 | ||||||
Rat | RGD:3444 | 24924 | ||||||
Dog | pleiotrophin | VGNC:45160 | 475509 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | pleiotrophin | |||||
Macaque | pleiotrophin | |||||
Mouse | ||||||
Rat | ||||||
Dog | pleiotrophin | |||||
Publication Statistics
PubMed Score 892.40
PubMed score by year
PubTator Score 370.83
PubTator score by year
Related Publications
Text Mined References (140)
GeneRif Annotations (98)
Items per page:
0 of 0
PMID | Year | Title |
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