Tbio PTK7 Inactive tyrosine-protein kinase 7

Protein Summary

Description

Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q13308
• A8K974
• B7Z477
• E9PFZ5
• Q13417
• Q5T650
• Q6IQ54
• Q8NFA5
• Q8NFA6
• Q8NFA7
• Q8NFA8

Gene Name

• PTK7

Ensembl ID

• ENST00000230418
• ENSP00000230418
• ENSG00000112655
• ENST00000230419
• ENSP00000230419
• ENST00000345201
• ENSP00000325992
• ENST00000349241
• ENSP00000325462
• ENST00000352931
• ENSP00000326029
• ENST00000481273
• ENSP00000418754

Symbol

• CCK4
• CCK4
• CCK-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.91
biological process	0.84
PubMedID	0.75
kinase perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Tyrosine Protein Kinase Receptor / Inactive Tyrosine-protein Kinase 7

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Inactive Tyrosine-protein Kinase 7

Protein / Receptor / Protein Kinase Receptor / Tyrosine Protein Kinase Receptor / Inactive Tyrosine-protein Kinase 7

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Cck4 Family / Inactive Tyrosine-protein Kinase 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 416.07   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 552   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 416.07   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 552   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0