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Tbio
PTK7
Inactive tyrosine-protein kinase 7

Protein Summary
Description
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230418
  • ENSP00000230418
  • ENSG00000112655
  • ENST00000230419
  • ENSP00000230419
  • ENST00000345201
  • ENSP00000325992
  • ENST00000349241
  • ENSP00000325462
  • ENST00000352931
  • ENSP00000326029
  • ENST00000481273
  • ENSP00000418754

Symbol
  • CCK4
  • CCK4
  • CCK-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.91
biological process
0.84
PubMedID
0.75
kinase perturbation
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 380.49   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 552   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 380.49   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 552   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.870605331
p_ni:  0.129394668
Data Source:  BioPlex
LY86
Tbio
Novelty:  0.00314575
p_int:  0.817697449
p_ni:  0.182302551
Data Source:  BioPlex
CCK
Tbio
Novelty:  0.00012268
Score:  0.838
Data Source:  STRINGDB
VANGL1
Tbio
Novelty:  0.00968008
Score:  0.77
Data Source:  STRINGDB
WNT5A
Tbio
Novelty:  0.00125563
Score:  0.755
Data Source:  STRINGDB
VANGL2
Tbio
Novelty:  0.00529796
Score:  0.75
Data Source:  STRINGDB
DVL1
Tchem
Novelty:  0.00356876
Score:  0.748
Data Source:  STRINGDB
CCKBR
Tclin
Family:  GPCR
Novelty:  0.00158159
Score:  0.747
Data Source:  STRINGDB
DVL3
Tbio
Novelty:  0.01606014
Score:  0.729
Data Source:  STRINGDB
CCKAR
Tclin
Family:  GPCR
Novelty:  0.00152339
Score:  0.719
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
39.6
waist-hip ratio
1
1
1
31.4
1
1
0
1.1
29
risk-taking behaviour
2
2
2
26.5
BMI-adjusted waist-hip ratio
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
39.6
waist-hip ratio
1
31.4
0
1.1
29
risk-taking behaviour
2
26.5
BMI-adjusted waist-hip ratio
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein tyrosine kinase 7 (inactive)
699791
Mouse
MGI:1918711
71461
Horse
protein tyrosine kinase 7 (inactive)
100067287
Opossum
protein tyrosine kinase 7 (inactive)
100011082
Fruitfly
FBgn0004839
36283
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein tyrosine kinase 7 (inactive)
Mouse
Horse
protein tyrosine kinase 7 (inactive)
Opossum
protein tyrosine kinase 7 (inactive)
Fruitfly
Publication Statistics
PubMed Score 380.49
PubMed score by year
PubTator Score 202.25
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title