You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
PTK2
Focal adhesion kinase 1

Protein Summary
Description
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340930
  • ENSP00000341189
  • ENSG00000169398
  • ENST00000395218
  • ENSP00000378644
  • ENST00000521059
  • ENSP00000429474
  • ENST00000522684
  • ENSP00000429911

Symbol
  • FAK
  • FAK1
  • FAK
  • FADK
  • FAK1
  • FRNK
  • PPP1R71
  • p125FAK
  • pp125FAK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
kinase
1
protein domain
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1358.32   (req: < 5)
Gene RIFs: 634   (req: <= 3)
Antibodies: 2638   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1358.32   (req: >= 5)
Gene RIFs: 634   (req: > 3)
Antibodies: 2638   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 389
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (443)
LPXN
Tbio
Novelty:  0.00796678
p_int:  0.999999767
p_ni:  2.3e-7
p_wrong:  3e-9
Score:  0.815
Data Source:  BioPlex,STRINGDB
PRKG1
Tchem
Family:  Kinase
Novelty:  0.0014943
p_int:  0.999999384
p_ni:  6.16e-7
Score:  0.461
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999998816
p_ni:  0.000001184
Data Source:  BioPlex
SERPINB2
Tbio
Novelty:  0.00204345
p_int:  0.999387053
p_ni:  0.000610187
p_wrong:  0.00000276
Score:  0.2
Data Source:  BioPlex,STRINGDB
PXN
Tbio
Novelty:  0.00082031
Score:  0.999
Data Source:  Reactome,STRINGDB
BCAR1
Tbio
Novelty:  0.00329214
Score:  0.995
Data Source:  Reactome,STRINGDB
PTEN
Tchem
Family:  Enzyme
Novelty:  0.00013818
Score:  0.993
Data Source:  STRINGDB
VCL
Tbio
Novelty:  0.00043107
Score:  0.989
Data Source:  STRINGDB
CTTN
Tbio
Novelty:  0.0017962
Score:  0.988
Data Source:  STRINGDB
DCC
Tbio
Novelty:  0.01273911
Score:  0.983
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (27)
Explore Nearest Tclin Targets
Pathways (139)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 45
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Axon guidance
Reactome
Cell-Cell communication
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Axon guidance
Cell-Cell communication
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (77)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
78
mathematical ability
3
2
3
72.8
diastolic blood pressure
1
1
1
64.9
2
3
0
1.1
60.2
self reported educational attainment
1
1
1
59.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
78
mathematical ability
3
72.8
diastolic blood pressure
1
64.9
0
1.1
60.2
self reported educational attainment
1
59.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine kinase 2
VGNC:813
464422
Mouse
MGI:95481
14083
Rat
RGD:3443
25614
Dog
protein tyrosine kinase 2
VGNC:45158
475108
Horse
protein tyrosine kinase 2
VGNC:22002
100058245
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine kinase 2
Mouse
Rat
Dog
protein tyrosine kinase 2
Horse
protein tyrosine kinase 2
Publication Statistics
PubMed Score 1358.32
PubMed score by year
PubTator Score 2038.33
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title