Protein Summary
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additi ...more
- ENST00000340930
- ENSP00000341189
- ENSG00000169398
- ENST00000395218
- ENSP00000378644
- ENST00000521059
- ENSP00000429474
- ENST00000522684
- ENSP00000429911
- FAK
- FAK1
- FAK
- FADK
- FAK1
- FRNK
- PPP1R71
- p125FAK
- pp125FAK
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
hub protein | 1 | ||
kinase | 1 | ||
protein domain | 1 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1358.32 (req: < 5)
Gene RIFs: 634 (req: <= 3)
Antibodies: 2638 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1358.32 (req: >= 5)
Gene RIFs: 634 (req: > 3)
Antibodies: 2638 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 65
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 389
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (389)
Protein-Protein Interactions (443)
LPXN
Novelty: 0.00796678
p_int: 0.999999767
p_ni: 2.3e-7
p_wrong: 3e-9
Score: 0.815
Data Source: BioPlex,STRINGDB
PRKG1
Family: Kinase
Novelty: 0.0014943
p_int: 0.999999384
p_ni: 6.16e-7
Score: 0.461
Data Source: BioPlex,STRINGDB
SERPINB2
Novelty: 0.00204345
p_int: 0.999387053
p_ni: 0.000610187
p_wrong: 0.00000276
Score: 0.2
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (27)
Upstream (19)
Downstream (8)
1 – 5 of 19
Pathways (139)
Reactome (45)
KEGG (20)
PathwayCommons (44)
WikiPathways (30)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Axon guidance | ||||
Reactome | Cell-Cell communication | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Apoptosis | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Axon guidance | ||||
Cell-Cell communication | ||||
Viral Interactions (0)
Gene Ontology Terms (77)
Functions (10)
Components (12)
Processes (55)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 78 | |||||
mathematical ability | 3 | 2 | 3 | 72.8 | |||||
diastolic blood pressure | 1 | 1 | 1 | 64.9 | |||||
2 | 3 | 0 | 1.1 | 60.2 | |||||
self reported educational attainment | 1 | 1 | 1 | 59.9 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 78 | |||||
mathematical ability | 3 | 72.8 | |||||
diastolic blood pressure | 1 | 64.9 | |||||
0 | 1.1 | 60.2 | |||||
self reported educational attainment | 1 | 59.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | protein tyrosine kinase 2 | VGNC:813 | 464422 | |||||
Mouse | MGI:95481 | 14083 | ||||||
Rat | RGD:3443 | 25614 | ||||||
Dog | protein tyrosine kinase 2 | VGNC:45158 | 475108 | |||||
Horse | protein tyrosine kinase 2 | VGNC:22002 | 100058245 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | protein tyrosine kinase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | protein tyrosine kinase 2 | |||||
Horse | protein tyrosine kinase 2 | |||||
Publication Statistics
PubMed Score 1358.32
PubMed score by year
PubTator Score 2038.33
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (797)
GeneRif Annotations (634)
Items per page:
0 of 0
PMID | Year | Title |
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