PTHLH
Parathyroid hormone-related protein
Protein Summary
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1. Osteos ...more
- ENST00000201015
- ENSP00000201015
- ENSG00000087494
- ENST00000395868
- ENSP00000379209
- ENST00000395872
- ENSP00000379213
- ENST00000535992
- ENSP00000440613
- ENST00000538310
- ENSP00000441890
- ENST00000539239
- ENSP00000441571
- ENST00000545234
- ENSP00000441765
- PTHRP
- HHM
- PLP
- BDE2
- PTHR
- PTHRP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.94 | ||
biological process | 0.91 | ||
PubMedID | 0.86 | ||
transcription factor perturbation | 0.84 | ||
chemical | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2334.29 (req: < 5)
Gene RIFs: 158 (req: <= 3)
Antibodies: 378 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2334.29 (req: >= 5)
Gene RIFs: 158 (req: > 3)
Antibodies: 378 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (216)
Nearest Tclin Targets
Pathways (23)
Reactome (6)
KEGG (1)
PathwayCommons (1)
WikiPathways (15)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (2)
Components (6)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
8 | 3 | 0 | 1.2 | 82.3 | |||||
2 | 2 | 0 | 1.2 | 76.6 | |||||
balding measurement | 2 | 4 | 4 | 46.1 | |||||
body height | 1 | 1 | 1 | 33 | |||||
4 | 2 | 0 | 1.1 | 29.9 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 82.3 | |||||
0 | 1.2 | 76.6 | |||||
balding measurement | 4 | 46.1 | |||||
body height | 1 | 33 | |||||
0 | 1.1 | 29.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | parathyroid hormone like hormone | VGNC:13373 | 473393 | |||||
Macaque | parathyroid hormone like hormone | 710295 | ||||||
Mouse | MGI:97800 | 19227 | ||||||
Dog | parathyroid hormone like hormone | VGNC:45157 | 403987 | |||||
Horse | parathyroid hormone like hormone | VGNC:22001 | 100033979 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | parathyroid hormone like hormone | |||||
Macaque | parathyroid hormone like hormone | |||||
Mouse | ||||||
Dog | parathyroid hormone like hormone | |||||
Horse | parathyroid hormone like hormone | |||||
Publication Statistics
PubMed Score 2334.29
PubMed score by year
PubTator Score 1550.41
PubTator score by year
Related Publications
Text Mined References (213)
GeneRif Annotations (158)
Items per page:
0 of 0
PMID | Year | Title |
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