Tchem PTH2R Parathyroid hormone 2 receptor

Protein Summary

Description

This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity). The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• P49190
• Q8N429
• PTH2 receptor

Gene Name

• PTH2R

Ensembl ID

• ENST00000272847
• ENSP00000272847
• ENSG00000144407

Symbol

• PTHR2
• PTHR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.78
gene perturbation	0.66
virus perturbation	0.64
protein domain	0.58
histone modification site profile	0.57

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class B Secretin Like / Parathyroid Hormone Receptor / Parathyroid Hormone 2 Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.91   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.91   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1