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Tclin
PTGS2
Prostaglandin G/H synthase 2

Protein Summary
Description
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367468
  • ENSP00000356438
  • ENSG00000073756

Symbol
  • COX2
  • COX2
  • COX-2
  • PHS-2
  • PGG/HS
  • PGHS-2
  • hCox-2
  • GRIPGHS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
drug
1
gene perturbation
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15741.16   (req: < 5)
Gene RIFs: 1962   (req: <= 3)
Antibodies: 875   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15741.16   (req: >= 5)
Gene RIFs: 1962   (req: > 3)
Antibodies: 875   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 73
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1856
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 55
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (55)
celecoxib
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indomethacin
Rendered image for indomethacin
flufenamic acid
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valdecoxib
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diclofenac
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mefenamic acid
Rendered image for mefenamic acid
sulindac
Rendered image for sulindac
meclofenamic acid
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sulfasalazine
Rendered image for sulfasalazine
niflumic acid
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Active Ligands (1856)
resveratrol
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nimesulide
Rendered image for nimesulide
CHEMBL3885367
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Phenothiazine
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pterostilbene
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CHEMBL3290441
Rendered image for CHEMBL3290441
tryptanthrin
Rendered image for tryptanthrin
CHEMBL3885496
Rendered image for CHEMBL3885496
SID11114082
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Protein-Protein Interactions (500)
LMAN2L
Tbio
Novelty:  0.04364985
p_int:  1
Score:  0.351
Data Source:  BioPlex,STRINGDB
PTGES
Tchem
Family:  Enzyme
Novelty:  0.00146096
Score:  0.984
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.98
Data Source:  STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
Score:  0.975
Data Source:  STRINGDB
IL1B
Tclin
Novelty:  0.0000308
Score:  0.974
Data Source:  STRINGDB
PTGIS
Tchem
Family:  Enzyme
Novelty:  0.00183292
Score:  0.974
Data Source:  STRINGDB
PTGDS
Tchem
Family:  Enzyme
Novelty:  0.002111
Score:  0.968
Data Source:  STRINGDB
PTGES2
Tchem
Family:  Enzyme
Novelty:  0.01415352
Score:  0.967
Data Source:  STRINGDB
CYP2E1
Tchem
Novelty:  0.00030504
Score:  0.964
Data Source:  STRINGDB
ALOX15
Tchem
Family:  Enzyme
Novelty:  0.00184734
Score:  0.959
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (65)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of DPA-derived SPMs
Reactome
Biosynthesis of DPAn-3 SPMs
Reactome
Biosynthesis of EPA-derived SPMs
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biosynthesis of DHA-derived SPMs
Biosynthesis of DPA-derived SPMs
Biosynthesis of DPAn-3 SPMs
Biosynthesis of EPA-derived SPMs
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (81)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sodium measurement
1
1
1
33.1
glomerular filtration rate
1
1
1
3.2
blood urea nitrogen measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sodium measurement
1
33.1
glomerular filtration rate
1
3.2
blood urea nitrogen measurement
1
0.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin-endoperoxide synthase 2
VGNC:6970
469616
Macaque
prostaglandin-endoperoxide synthase 2
716671
Mouse
MGI:97798
19225
Rat
RGD:620349
29527
Dog
prostaglandin-endoperoxide synthase 2
VGNC:45152
442942
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin-endoperoxide synthase 2
Macaque
prostaglandin-endoperoxide synthase 2
Mouse
Rat
Dog
prostaglandin-endoperoxide synthase 2
Publication Statistics
PubMed Score 15741.16
PubMed score by year
PubTator Score 8401.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title