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Tclin
PTGS2
Prostaglandin G/H synthase 2

Protein Summary
Description
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367468
  • ENSP00000356438
  • ENSG00000073756

Symbol
  • COX2
  • COX2
  • COX-2
  • PHS-2
  • PGG/HS
  • PGHS-2
  • hCox-2
  • GRIPGHS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
drug
1
gene perturbation
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16858.93   (req: < 5)
Gene RIFs: 2120   (req: <= 3)
Antibodies: 875   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16858.93   (req: >= 5)
Gene RIFs: 2120   (req: > 3)
Antibodies: 875   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 73
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1939
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 55