Tclin PTGS1 Prostaglandin G/H synthase 1

Protein Summary

Description

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• P23219
• A8K1V7
• B4DHQ2
• B4E2S5
• Q15122
• Q3HY28
• Q3HY29
• Q5T7T6
• Q5T7T7
• Q5T7T8

Gene Name

• PTGS1

Ensembl ID

• ENST00000223423
• ENSP00000223423
• ENSG00000095303
• ENST00000362012
• ENSP00000354612
• ENST00000373698
• ENSP00000362802
• ENST00000540753
• ENSP00000437709
• ENST00000614910
• ENSP00000484800

Symbol

• COX1
• COX1
• COX3
• PHS1
• PCOX1
• PES-1
• PGHS1
• PTGHS
• PGG/HS
• PGHS-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1
chemical	0.97
PubMedID	0.97
transcription factor perturbation	0.96
biological term	0.95

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Prostaglandin G/h Synthase 1

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / Prostaglandin G/h Synthase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2615.98   (req: < 5)

Gene RIFs: 203   (req: <= 3)

Antibodies: 627   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2615.98   (req: >= 5)

Gene RIFs: 203   (req: > 3)

Antibodies: 627   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 333

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 42