Tclin PTGIR Prostacyclin receptor

Protein Summary

Description

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P43119

Gene Name

• PTGIR

Ensembl ID

• ENST00000291294
• ENSP00000291294
• ENSG00000160013

Symbol

• PRIPR
• IP
• PRIPR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.76
biological process	0.73
tissue sample	0.68
tissue	0.67
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Prostacyclin Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Prostacyclin Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.78   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 240   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.78   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 188

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6