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Tchem
PTGES2
Prostaglandin E synthase 2

Protein Summary
Description
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2). The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338961
  • ENSP00000345341
  • ENSG00000148334

Symbol
  • C9orf15
  • PGES2
  • GBF1
  • GBF-1
  • PGES2
  • C9orf15
  • mPGES-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
interacting protein
0.86
transcription factor binding site profile
0.85
protein domain
0.73
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.2   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.2   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 133
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (133)
CHEMBL180650
Rendered image for CHEMBL180650
CHEMBL180617
Rendered image for CHEMBL180617
CHEMBL182032,CHEMBL3758663
Rendered image for CHEMBL182032,CHEMBL3758663
CHEMBL362242
Rendered image for CHEMBL362242
CHEMBL181236
Rendered image for CHEMBL181236
CHEMBL360114
Rendered image for CHEMBL360114
CHEMBL369525
Rendered image for CHEMBL369525
CHEMBL368241
Rendered image for CHEMBL368241
CHEMBL362836
Rendered image for CHEMBL362836
CHEMBL181728
Rendered image for CHEMBL181728
Protein-Protein Interactions (155)
UQCRB
Tbio
Novelty:  0.02933046
p_int:  0.999976409
p_ni:  0.000023591
Score:  0.273
Data Source:  BioPlex,STRINGDB
MT-CYB
Tbio
Novelty:  0.00012093
p_int:  0.999900327
p_ni:  0.000030095
p_wrong:  0.000069578
Data Source:  BioPlex
COX7A2L
Tbio
Family:  Enzyme
Novelty:  0.06920916
p_int:  0.999874921
p_ni:  0.000097885
p_wrong:  0.000027194
Data Source:  BioPlex
SHISA2
Tbio
Novelty:  0.18786159
p_int:  0.999861118
p_ni:  0.000138882
Score:  0.537
Data Source:  BioPlex,STRINGDB
UQCRFS1
Tbio
Novelty:  0.00341256
p_int:  0.999816252
p_ni:  0.000183748
Score:  0.201
Data Source:  BioPlex,STRINGDB
NF1
Tbio
Novelty:  0.00019092
p_int:  0.999751202
p_ni:  0.000248798
Data Source:  BioPlex
ESRRA
Tchem
Family:  NR
Novelty:  0.003235
p_int:  0.998276647
p_ni:  1.3e-8
p_wrong:  0.00172334
Score:  0.171
Data Source:  BioPlex,STRINGDB
USP1
Tchem
Family:  Enzyme
Novelty:  0.0092606
p_int:  0.996239394
p_ni:  0.003760606
Data Source:  BioPlex
ABCF2
Tbio
Family:  Transporter
Novelty:  0.06782708
p_int:  0.988807309
p_ni:  0.011192691
Score:  0.27
Data Source:  BioPlex,STRINGDB
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
p_int:  0.986391654
p_ni:  0.013608346
Data Source:  BioPlex
Pathways (14)
Arachidonic acid metabolism (R-HSA-2142753)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Immune System
Innate Immune System
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
54.5
blood protein measurement
1
1
1
40.8
body mass index
1
1
1
32.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
54.5
blood protein measurement
1
40.8
body mass index
1
32.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin E synthase 2
VGNC:4837
464763
Macaque
prostaglandin E synthase 2
697949
Mouse
MGI:1917592
96979
Rat
RGD:1310836
311865
Dog
prostaglandin E synthase 2
VGNC:45146
609101
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin E synthase 2
Macaque
prostaglandin E synthase 2
Mouse
Rat
Dog
prostaglandin E synthase 2
Publication Statistics
PubMed Score 62.20
PubMed score by year
PubTator Score 16.94
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title