Protein Summary
Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]
- ENST00000340607
- ENSP00000342385
- ENSG00000148344
- MGST1L1
- MPGES1
- PGES
- PIG12
- PGES
- MPGES
- PIG12
- PP102
- PP1294
- MGST-IV
- MGST1L1
- TP53I12
- mPGES-1
- MGST1-L1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.87 | ||
PubMedID | 0.82 | ||
biological term | 0.8 | ||
disease | 0.75 | ||
small molecule perturbation | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 781.31 (req: < 5)
Gene RIFs: 118 (req: <= 3)
Antibodies: 203 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 781.31 (req: >= 5)
Gene RIFs: 118 (req: > 3)
Antibodies: 203 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1106
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (1106)
Protein-Protein Interactions (69)
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
Pathways (15)
Reactome (5)
KEGG (2)
PathwayCommons (1)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Arachidonic acid metabolism | ||||
Reactome | Fatty acid metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Arachidonic acid metabolism | ||||
Fatty acid metabolism | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (3)
Components (6)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
serum alanine aminotransferase measurement | 2 | 1 | 1 | 5.6 | 64.9 | ||||
1 | 1 | 0 | 1.1 | 35 | |||||
liver fat measurement | 1 | 1 | 1 | 29 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum alanine aminotransferase measurement | 1 | 5.6 | 64.9 | ||||
0 | 1.1 | 35 | |||||
liver fat measurement | 1 | 29 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | prostaglandin E synthase | VGNC:4836 | 473071 | |||||
Macaque | prostaglandin E synthase | 716657 | ||||||
Mouse | MGI:1927593 | 64292 | ||||||
Rat | RGD:62076 | 59103 | ||||||
Dog | prostaglandin E synthase | VGNC:45145 | 480698 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | prostaglandin E synthase | |||||
Macaque | prostaglandin E synthase | |||||
Mouse | ||||||
Rat | ||||||
Dog | prostaglandin E synthase | |||||
Publication Statistics
PubMed Score 781.31
PubMed score by year
PubTator Score 240.22
PubTator score by year
Related Publications
Text Mined References (142)
GeneRif Annotations (118)
Items per page:
0 of 0
PMID | Year | Title |
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