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Tchem
PTGES
Prostaglandin E synthase

Protein Summary
Description
Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340607
  • ENSP00000342385
  • ENSG00000148344

Symbol
  • MGST1L1
  • MPGES1
  • PGES
  • PIG12
  • PGES
  • MPGES
  • PIG12
  • PP102
  • PP1294
  • MGST-IV
  • MGST1L1
  • TP53I12
  • mPGES-1
  • MGST1-L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
PubMedID
0.82
biological term
0.8
disease
0.75
small molecule perturbation
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 781.31   (req: < 5)
Gene RIFs: 118   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 781.31   (req: >= 5)
Gene RIFs: 118   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1106
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (69)
PTGS2
Tclin
Family:  Enzyme
Novelty:  0.00007089
Score:  0.984
Data Source:  STRINGDB
PTGES2
Tchem
Family:  Enzyme
Novelty:  0.01415352
Score:  0.978
Data Source:  STRINGDB
PTGES3
Tbio
Family:  Enzyme
Novelty:  0.0082783
Score:  0.973
Data Source:  STRINGDB
PTGS1
Tclin
Family:  Enzyme
Novelty:  0.00043214
Score:  0.97
Data Source:  STRINGDB
TBXAS1
Tchem
Family:  Enzyme
Novelty:  0.0053649
Score:  0.966
Data Source:  STRINGDB
PTGIS
Tchem
Family:  Enzyme
Novelty:  0.00183292
Score:  0.966
Data Source:  STRINGDB
PTGDS
Tchem
Family:  Enzyme
Novelty:  0.002111
Score:  0.963
Data Source:  STRINGDB
HPGDS
Tchem
Family:  Enzyme
Novelty:  0.00019629
Score:  0.945
Data Source:  STRINGDB
CBR1
Tchem
Family:  Enzyme
Novelty:  0.0062295
Score:  0.943
Data Source:  STRINGDB
CBR3
Tbio
Family:  Enzyme
Novelty:  0.01874422
Score:  0.902
Data Source:  STRINGDB
Pathways (15)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
2
1
1
5.6
64.9
1
1
0
1.1
35
liver fat measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
1
5.6
64.9
0
1.1
35
liver fat measurement
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin E synthase
VGNC:4836
473071
Macaque
prostaglandin E synthase
716657
Mouse
MGI:1927593
64292
Rat
RGD:62076
59103
Dog
prostaglandin E synthase
VGNC:45145
480698
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin E synthase
Macaque
prostaglandin E synthase
Mouse
Rat
Dog
prostaglandin E synthase
Publication Statistics
PubMed Score 781.31
PubMed score by year
PubTator Score 240.22
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title