Tclin PTGER4 Prostaglandin E2 receptor EP4 subtype

Protein Summary

Description

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35408
• Q3MJ87
• PGE receptor EP4 subtype

Gene Name

• PTGER4

Ensembl ID

• ENST00000302472
• ENSP00000302846
• ENSG00000171522

Symbol

• PTGER2
• EP4
• EP4R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
transcription factor perturbation	1
gene perturbation	0.97
ligand (chemical)	0.97
biological process	0.94

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Prostaglandin E2 Receptor Ep4 Subtype

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Prostaglandin E2 Receptor Ep4 Subtype

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1439.19   (req: < 5)

Gene RIFs: 147   (req: <= 3)

Antibodies: 341   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1439.19   (req: >= 5)

Gene RIFs: 147   (req: > 3)

Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 466

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6