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Tchem
PTGDS
Prostaglandin-H2 D-isomerase

Protein Summary
Description
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371625
  • ENSP00000360687
  • ENSG00000107317

Symbol
  • PDS
  • PDS
  • PGD2
  • PGDS
  • LPGDS
  • PGDS2
  • L-PGDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
small molecule perturbation
0.98
disease perturbation
0.87
protein domain
0.85
cellular component
0.84


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 516.19   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 516.19   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (65)
ORM1
Tbio
Novelty:  0.007451
p_int:  0.939966705
p_ni:  0.051834683
p_wrong:  0.008198613
Score:  0.587
Data Source:  BioPlex,STRINGDB
CHN2
Tbio
Novelty:  0.01065579
p_int:  0.839219465
p_ni:  5.2e-7
p_wrong:  0.160780015
Score:  0.703
Data Source:  BioPlex,STRINGDB
PTGS2
Tclin
Family:  Enzyme
Novelty:  0.00007089
Score:  0.968
Data Source:  STRINGDB
PTGES
Tchem
Family:  Enzyme
Novelty:  0.00146096
Score:  0.963
Data Source:  STRINGDB
PTGES2
Tchem
Family:  Enzyme
Novelty:  0.01415352
Score:  0.954
Data Source:  STRINGDB
TBXAS1
Tchem
Family:  Enzyme
Novelty:  0.0053649
Score:  0.954
Data Source:  STRINGDB
PTGIS
Tchem
Family:  Enzyme
Novelty:  0.00183292
Score:  0.953
Data Source:  STRINGDB
PTGS1
Tclin
Family:  Enzyme
Novelty:  0.00043214
Score:  0.951
Data Source:  STRINGDB
PTGES3
Tbio
Family:  Enzyme
Novelty:  0.0082783
Score:  0.948
Data Source:  STRINGDB
HPGDS
Tchem
Family:  Enzyme
Novelty:  0.00019629
Score:  0.947
Data Source:  STRINGDB
Pathways (13)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Fatty acid metabolism
Metabolism
Metabolism of lipids
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
3
4
91.5
monocyte percentage of leukocytes
2
2
2
88
leukocyte count
2
2
3
70.2
central corneal thickness
3
2
0
2.9
69.8
lymphocyte percentage of leukocytes
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
91.5
monocyte percentage of leukocytes
2
88
leukocyte count
3
70.2
central corneal thickness
0
2.9
69.8
lymphocyte percentage of leukocytes
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin D2 synthase
100610452
Macaque
prostaglandin D2 synthase
707990
Mouse
MGI:99261
19215
Rat
RGD:3433
25526
Dog
prostaglandin D2 synthase
403740
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin D2 synthase
Macaque
prostaglandin D2 synthase
Mouse
Rat
Dog
prostaglandin D2 synthase
Publication Statistics
PubMed Score 516.19
PubMed score by year
PubTator Score 1050.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title