Tchem PTGDR2 Prostaglandin D2 receptor 2

Protein Summary

Description

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q9Y5Y4
• O94765
• Q4QRI6

Gene Name

• PTGDR2

Ensembl ID

• ENST00000332539
• ENSP00000332812
• ENSG00000183134

Symbol

• CRTH2
• DL1R
• GPR44
• DP2
• DL1R
• CD294
• CRTH2
• GPR44

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.72
biological term	0.62
molecular function	0.6
phenotype	0.57
cell line	0.55

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Prostaglandin D2 Receptor 2

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Prostaglandin D2 Receptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 385.43   (req: < 5)

Gene RIFs: 65   (req: <= 3)

Antibodies: 598   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 385.43   (req: >= 5)

Gene RIFs: 65   (req: > 3)

Antibodies: 598   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2059

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4