Tbio PTCRA Pre T-cell antigen receptor alpha

Protein Summary

Description

The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

Uniprot Accession IDs

• Q6ISU1
• Q5TFZ7
• pT-alpha

Gene Name

• PTCRA

Ensembl ID

• ENST00000304672
• ENSP00000304447
• ENSG00000171611
• ENST00000441198
• ENSP00000409550
• ENST00000446507
• ENSP00000392288

Symbol

• PTA
• PT-ALPHA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.69
cell line	0.54
gene perturbation	0.52
small molecule perturbation	0.52
disease perturbation	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.8   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 114   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.8   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0