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Tdark
PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

Protein Summary
Description
Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308077
  • ENSP00000308948
  • ENSG00000049883
  • ENST00000380639
  • ENSP00000370013
  • ENST00000503868
  • ENSP00000427349
  • ENST00000536805
  • ENSP00000444772
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
histone modification site profile
0.89
kinase perturbation
0.84
transcription factor binding site profile
0.71
tissue sample
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.58   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.58   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
SLAMF7
Tclin
Novelty:  0.01014396
p_int:  0.995133836
p_ni:  0.004866164
Score:  0.205
Data Source:  BioPlex,STRINGDB
VTN
Tbio
Family:  TF
Novelty:  0.00046861
p_int:  0.993934244
p_ni:  0.006065756
Data Source:  BioPlex
GTF2A1
Tchem
Novelty:  0.19577296
p_int:  0.991264691
p_ni:  0.008735309
Score:  0.211
Data Source:  BioPlex,STRINGDB
SALL2
Tbio
Family:  TF
Novelty:  0.01181421
p_int:  0.990836294
p_ni:  0.009163706
Data Source:  BioPlex
VSIG4
Tbio
Novelty:  0.01671671
p_int:  0.962577644
p_ni:  0.037422356
Data Source:  BioPlex
NTRK3
Tclin
Family:  Kinase
Novelty:  0.00177321
p_int:  0.961510215
p_ni:  0.038489784
Data Source:  BioPlex
TMEM154
Tdark
Novelty:  0.08935925
p_int:  0.926387891
p_ni:  0.073612075
p_wrong:  3.4e-8
Data Source:  BioPlex
CA6
Tclin
Family:  Enzyme
Novelty:  0.00293722
p_int:  0.897044179
p_ni:  0.102953534
p_wrong:  0.000002286
Data Source:  BioPlex
CDH8
Tbio
Novelty:  0.04055999
p_int:  0.884979041
p_ni:  0.114341494
p_wrong:  0.000679465
Score:  0.183
Data Source:  BioPlex,STRINGDB
CD14
Tbio
Novelty:  0.00872424
p_int:  0.837322817
p_ni:  0.153756011
p_wrong:  0.008921172
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
4
4
95.6
monocyte count
2
2
2
89.5
myeloid white cell count
2
2
2
84.1
leukocyte count
2
2
2
81
lymphocyte percentage of leukocytes
1
2
2
79.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
4
95.6
monocyte count
2
89.5
myeloid white cell count
2
84.1
leukocyte count
2
81
lymphocyte percentage of leukocytes
2
79.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pentatricopeptide repeat domain 2
VGNC:4138
461820
Mouse
MGI:1916177
68927
Rat
RGD:1310308
310025
Dog
pentatricopeptide repeat domain 2
VGNC:45131
610392
Horse
pentatricopeptide repeat domain 2 [Source:HGNC Symbol;Acc:HGNC:25734]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pentatricopeptide repeat domain 2
Mouse
Rat
Dog
pentatricopeptide repeat domain 2
Horse
pentatricopeptide repeat domain 2 [Source:HGNC Symbol;Acc:HGNC:25734]
Publication Statistics
PubMed Score 4.58
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title