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Tbio
PTBP1
Polypyrimidine tract-binding protein 1

Protein Summary
Description
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806). This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA proce ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349038
  • ENSP00000014112
  • ENSG00000011304
  • ENST00000356948
  • ENSP00000349428
  • ENST00000394601
  • ENSP00000408096

Symbol
  • PTB
  • PTB
  • PTB2
  • PTB3
  • PTB4
  • pPTB
  • HNRPI
  • PTB-1
  • PTB-T
  • HNRNPI
  • HNRNP-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor binding site profile
0.96
kinase perturbation
0.95
hub protein
0.88
ligand (protein) perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 664.65   (req: < 5)
Gene RIFs: 87   (req: <= 3)
Antibodies: 404   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 664.65   (req: >= 5)
Gene RIFs: 87   (req: > 3)
Antibodies: 404   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0