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Tbio
PSRC1
Proline/serine-rich coiled-coil protein 1

Protein Summary
Description
Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369903
  • ENSP00000358919
  • ENSG00000134222
  • ENST00000369904
  • ENSP00000358920
  • ENST00000369907
  • ENSP00000358923
  • ENST00000369909
  • ENSP00000358925
  • ENST00000409138
  • ENSP00000474667
  • ENST00000409267
  • ENSP00000386323

Symbol
  • DDA3
  • DDA3
  • FP3214
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
biological process
0.79
virus perturbation
0.76
trait
0.75
drug perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.2   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.2   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
PRMT2
Tbio
Family:  Epigenetic
Novelty:  0.04121581
p_int:  0.999407643
p_ni:  0.000038967
p_wrong:  0.00055339
Score:  0.258
Data Source:  BioPlex,STRINGDB
FUS
Tbio
Novelty:  0.00065625
p_int:  0.786001163
p_ni:  0.213998837
Score:  0.38
Data Source:  BioPlex,STRINGDB
CELSR2
Tbio
Family:  GPCR
Novelty:  0.02657319
Score:  0.876
Data Source:  STRINGDB
SORT1
Tchem
Novelty:  0.00319862
Score:  0.798
Data Source:  STRINGDB
KIF2A
Tbio
Novelty:  0.01463006
Score:  0.716
Data Source:  STRINGDB
ASB7
Tbio
Novelty:  0.21883348
Score:  0.714
Data Source:  STRINGDB
MYBPHL
Tbio
Novelty:  0.31786873
Score:  0.701
Data Source:  STRINGDB
SYPL2
Tdark
Novelty:  0.03928948
Score:  0.654
Data Source:  STRINGDB
VPS54
Tbio
Novelty:  0.04428383
Score:  0.652
Data Source:  STRINGDB
MIA3
Tbio
Novelty:  0.02784348
Score:  0.643
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Aryl Hydrocarbon Receptor
WikiPathways
Aryl Hydrocarbon Receptor
WikiPathways
Ras Signaling
WikiPathways
Fragile X Syndrome
WikiPathways
Synaptic signaling pathways associated with autism spectrum disorder
Name
Explore in Pharos
Explore in Source
Aryl Hydrocarbon Receptor
Aryl Hydrocarbon Receptor
Ras Signaling
Fragile X Syndrome
Synaptic signaling pathways associated with autism spectrum disorder
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (73)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
111
31
151
6
100
total cholesterol measurement
39
24
74
6.2
99.9
13
6
4
1.1
99.5
high density lipoprotein cholesterol measurement
38
12
55
99.4
apolipoprotein B measurement
6
23
26
98.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
151
6
100
total cholesterol measurement
74
6.2
99.9
4
1.1
99.5
high density lipoprotein cholesterol measurement
55
99.4
apolipoprotein B measurement
26
98.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proline and serine rich coiled-coil 1
VGNC:10034
457088
Macaque
proline and serine rich coiled-coil 1
698060
Mouse
MGI:1913099
56742
Rat
RGD:1585037
691380
Dog
proline and serine rich coiled-coil 1
VGNC:45125
611844
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proline and serine rich coiled-coil 1
Macaque
proline and serine rich coiled-coil 1
Mouse
Rat
Dog
proline and serine rich coiled-coil 1
Publication Statistics
PubMed Score 46.20
PubMed score by year
PubTator Score 20.86
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title