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Tbio
PSPC1
Paraspeckle component 1

Protein Summary
Description
Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338910
  • ENSP00000343966
  • ENSG00000121390
  • ENST00000471658
  • ENSP00000436038
  • ENST00000492741
  • ENSP00000435921
  • ENST00000619300
  • ENSP00000481916

Symbol
  • PSP1
  • PSP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
virus perturbation
0.92
hub protein
0.79
tissue sample
0.73
protein complex
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.61   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.61   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
SFPQ
Tbio
Novelty:  0.01207637
p_int:  0.999976162
p_ni:  0.000023838
Score:  0.991
Data Source:  BioPlex,STRINGDB
NONO
Tbio
Novelty:  0.00501502
p_int:  0.998828269
p_ni:  0.001171731
Score:  0.995
Data Source:  BioPlex,STRINGDB
CCDC22
Tbio
Novelty:  0.01400901
p_int:  0.998474832
p_ni:  0.001525168
Score:  0.675
Data Source:  BioPlex,STRINGDB
ORC6
Tbio
Novelty:  0.02529139
p_int:  0.921456097
p_ni:  0.078543903
Score:  0.332
Data Source:  BioPlex,STRINGDB
TATDN1
Tbio
Family:  Enzyme
Novelty:  0.12964405
Score:  0.866
Data Source:  STRINGDB
PPP5C
Tbio
Family:  Enzyme
Novelty:  0.01990823
Score:  0.847
Data Source:  STRINGDB
RBM14
Tbio
Novelty:  0.01286049
Score:  0.797
Data Source:  STRINGDB
CIZ1
Tbio
Novelty:  0.03730538
Score:  0.717
Data Source:  STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.684
Data Source:  STRINGDB
ZMYM4
Tbio
Novelty:  0.08839944
Score:  0.604
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Circadian rhythm related genes
WikiPathways
Circadian rhythm related genes
WikiPathways
Circadian rhythm related genes
WikiPathways
Circadian rhythm related genes
WikiPathways
Circadian rhythm related genes
Name
Explore in Pharos
Explore in Source
Circadian rhythm related genes
Circadian rhythm related genes
Circadian rhythm related genes
Circadian rhythm related genes
Circadian rhythm related genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
paraspeckle component 1
VGNC:5098
452452
Macaque
paraspeckle component 1
705080
Mouse
MGI:1913895
66645
Rat
RGD:1310122
305910
Horse
paraspeckle component 1
VGNC:21971
100053345
Species
Name
OMA
EggNOG
Inparanoid
Chimp
paraspeckle component 1
Macaque
paraspeckle component 1
Mouse
Rat
Horse
paraspeckle component 1
Publication Statistics
PubMed Score 98.61
PubMed score by year
PubTator Score 40.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title