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Tdark
PSMG4
Proteasome assembly chaperone 4

Protein Summary
Description
Chaperone protein which promotes assembly of the 20S proteasome.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000419065
  • ENSP00000392353
  • ENSG00000180822
  • ENST00000438998
  • ENSP00000413353
  • ENST00000473000
  • ENSP00000418241

Symbol
  • C6orf86
  • PAC4
  • PAC4
  • C6orf86
  • bA506K6.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.66
tissue sample
0.64
transcription factor binding site profile
0.59
gene perturbation
0.56
transcription factor
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.62   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.62   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
PSMA5
Tbio
Family:  Enzyme
Novelty:  0.03862668
p_int:  0.999999698
p_ni:  3.02e-7
Score:  0.151
Data Source:  BioPlex,STRINGDB
PSMA1
Tclin
Family:  Enzyme
Novelty:  0.013722
p_int:  0.999999437
p_ni:  5.63e-7
Score:  0.707
Data Source:  BioPlex,STRINGDB
PSMG2
Tbio
Novelty:  0.11082503
p_int:  0.99999712
p_ni:  0.00000288
Score:  0.966
Data Source:  BioPlex,STRINGDB
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.999924654
p_ni:  0.000075341
p_wrong:  5e-9
Score:  0.162
Data Source:  BioPlex,STRINGDB
CCDC69
Tdark
Novelty:  0.37983713
p_int:  0.999690755
p_ni:  0.000309237
p_wrong:  8e-9
Data Source:  BioPlex
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.99957751
p_ni:  0.000422039
p_wrong:  4.51e-7
Score:  0.775
Data Source:  BioPlex,STRINGDB
PSMB3
Tbio
Family:  Enzyme
Novelty:  0.12791198
p_int:  0.999138111
p_ni:  0.000861326
p_wrong:  5.63e-7
Score:  0.504
Data Source:  BioPlex,STRINGDB
PPM1E
Tbio
Family:  Enzyme
Novelty:  0.08964901
p_int:  0.997615866
p_ni:  0.002367953
p_wrong:  0.000016181
Score:  0.188
Data Source:  BioPlex,STRINGDB
CA10
Tbio
Family:  Enzyme
Novelty:  0.01053152
p_int:  0.997489567
p_ni:  0.00248752
p_wrong:  0.000022913
Score:  0.529
Data Source:  BioPlex,STRINGDB
ZMAT5
Tdark
Novelty:  0.97115324
p_int:  0.993095766
p_ni:  0.006887155
p_wrong:  0.000017079
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
5
6
88.3
electrocardiography
1
1
33
56.4
mean platelet volume
1
1
1
45.2
mean reticulocyte volume
1
1
1
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
88.3
electrocardiography
33
56.4
mean platelet volume
1
45.2
mean reticulocyte volume
1
4.7
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome assembly chaperone 4
VGNC:9596
462401
Macaque
proteasome assembly chaperone 4
708514
Mouse
MGI:1916916
69666
Rat
RGD:1589955
689623
Cow
proteasome assembly chaperone 4
VGNC:33481
789063
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome assembly chaperone 4
Macaque
proteasome assembly chaperone 4
Mouse
Rat
Cow
proteasome assembly chaperone 4
Publication Statistics
PubMed Score 16.62
PubMed score by year
PubTator Score 10.75
PubTator score by year
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Related Publications
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PMID
Year
Title