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Tchem
PSMG3
Proteasome assembly chaperone 3

Protein Summary
Description
Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252329
  • ENSP00000252329
  • ENSG00000157778
  • ENST00000288607
  • ENSP00000288607
  • ENST00000404674
  • ENSP00000384799

Symbol
  • C7orf48
  • PAC3
  • PAC3
  • C7orf48
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
transcription factor binding site profile
0.78
kinase perturbation
0.66
tissue sample
0.64
transcription factor
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.48   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.48   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (66)
PSMA5
Tbio
Family:  Enzyme
Novelty:  0.03862668
p_int:  0.999993026
p_ni:  0.000006973
Score:  0.329
Data Source:  BioPlex,STRINGDB
PSMA1
Tclin
Family:  Enzyme
Novelty:  0.013722
p_int:  0.999972196
p_ni:  0.000027804
Score:  0.708
Data Source:  BioPlex,STRINGDB
PSMG2
Tbio
Novelty:  0.11082503
p_int:  0.999677282
p_ni:  0.000322718
Score:  0.955
Data Source:  BioPlex,STRINGDB
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.999598334
p_ni:  0.000401665
p_wrong:  1e-9
Score:  0.737
Data Source:  BioPlex,STRINGDB
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.998709714
p_ni:  0.001290261
p_wrong:  2.6e-8
Data Source:  BioPlex
CCDC69
Tdark
Novelty:  0.37983713
p_int:  0.99842455
p_ni:  0.001575449
p_wrong:  1e-9
Data Source:  BioPlex
PSMB3
Tbio
Family:  Enzyme
Novelty:  0.12791198
p_int:  0.998167833
p_ni:  0.0018313
p_wrong:  8.68e-7
Score:  0.418
Data Source:  BioPlex,STRINGDB
AVPI1
Tdark
Novelty:  0.28472403
p_int:  0.996864184
p_ni:  0.003135802
p_wrong:  1.3e-8
Data Source:  BioPlex
AMACR
Tbio
Family:  Enzyme
Novelty:  0.00218306
p_int:  0.996645355
p_ni:  0.003354644
Score:  0.189
Data Source:  BioPlex,STRINGDB
PPM1E
Tbio
Family:  Enzyme
Novelty:  0.08964901
p_int:  0.996331652
p_ni:  0.003668319
p_wrong:  2.9e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking initiation
2
2
2
46
smoking status measurement
2
1
2
13.5
smoking behavior
1
1
1
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking initiation
2
46
smoking status measurement
2
13.5
smoking behavior
1
6.3
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
proteasome assembly chaperone 3
697590
Mouse
MGI:1913756
66506
Rat
RGD:2319950
100361517
Dog
proteasome assembly chaperone 3
VGNC:45123
479769
Horse
proteasome assembly chaperone 3
VGNC:21970
100053289
Species
Name
OMA
EggNOG
Inparanoid
Macaque
proteasome assembly chaperone 3
Mouse
Rat
Dog
proteasome assembly chaperone 3
Horse
proteasome assembly chaperone 3
Publication Statistics
PubMed Score 62.48
PubMed score by year
PubTator Score 22.62
PubTator score by year
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Related Publications
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PMID
Year
Title