Tbio PSMG2 Proteasome assembly chaperone 2

Protein Summary

Description

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.

Uniprot Accession IDs

• Q969U7
• B0YJB3
• Q6IAH4
• Q9NRV1
• V9GYH7
• PAC-2

Gene Name

• PSMG2

Ensembl ID

• ENST00000317615
• ENSP00000325919
• ENSG00000128789
• ENST00000585331
• ENSP00000476763

Symbol

• HCCA3
• PAC2
• TNFSF5IP1
• PAC2
• HCCA3
• CLAST3
• MDS003
• HsT1707
• TNFSF5IP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.79
kinase perturbation	0.76
transcription factor perturbation	0.74
tissue sample	0.72
biological process	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.9   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 214   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.9   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0