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Tbio
PSMG2
Proteasome assembly chaperone 2

Protein Summary
Description
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317615
  • ENSP00000325919
  • ENSG00000128789
  • ENST00000585331
  • ENSP00000476763

Symbol
  • HCCA3
  • PAC2
  • TNFSF5IP1
  • PAC2
  • HCCA3
  • CLAST3
  • MDS003
  • HsT1707
  • TNFSF5IP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
kinase perturbation
0.76
transcription factor perturbation
0.74
tissue sample
0.72
biological process
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.67   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.67   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.999999985
p_ni:  1.5e-8
Score:  0.925
Data Source:  BioPlex,STRINGDB
PSMG1
Tbio
Novelty:  0.08175356
p_int:  0.999999813
p_ni:  1.77e-7
p_wrong:  1e-8
Score:  0.959
Data Source:  BioPlex,STRINGDB
PSMA5
Tbio
Family:  Enzyme
Novelty:  0.03862668
p_int:  0.999998896
p_ni:  0.000001104
Score:  0.99
Data Source:  BioPlex,STRINGDB
PSMG4
Tdark
Novelty:  0.05339077
p_int:  0.99999712
p_ni:  0.00000288
Score:  0.966
Data Source:  BioPlex,STRINGDB
PSMA1
Tclin
Family:  Enzyme
Novelty:  0.013722
p_int:  0.999996609
p_ni:  0.000003391
Score:  0.994
Data Source:  BioPlex,STRINGDB
PSMF1
Tbio
Novelty:  0.0364376
p_int:  0.999980186
p_ni:  0.000019814
Score:  0.85
Data Source:  BioPlex,STRINGDB
PSMB2
Tclin
Family:  Enzyme
Novelty:  0.06714761
p_int:  0.999978563
p_ni:  0.000021437
Score:  0.968
Data Source:  BioPlex,STRINGDB
PSMB1
Tclin
Family:  Enzyme
Novelty:  0.0255917
p_int:  0.999976615
p_ni:  0.000023385
Score:  0.981
Data Source:  BioPlex,STRINGDB
POMP
Tbio
Novelty:  0.01885028
p_int:  0.999973168
p_ni:  0.000026832
Score:  0.982
Data Source:  BioPlex,STRINGDB
PSMB3
Tbio
Family:  Enzyme
Novelty:  0.12791198
p_int:  0.999928381
p_ni:  0.000071619
Score:  0.973
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
2
2
89
4
2
0
1.2
80.2
2
1
0
1.2
78.4
3
2
0
1.3
68.2
juvenile idiopathic arthritis
1
1
0
1.3
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
89
0
1.2
80.2
0
1.2
78.4
0
1.3
68.2
juvenile idiopathic arthritis
0
1.3
61
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome assembly chaperone 2
VGNC:9914
748322
Macaque
proteasome assembly chaperone 2
702480
Mouse
MGI:1922901
107047
Rat
RGD:1304867
291539
Dog
proteasome assembly chaperone 2
VGNC:45122
480215
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome assembly chaperone 2
Macaque
proteasome assembly chaperone 2
Mouse
Rat
Dog
proteasome assembly chaperone 2
Publication Statistics
PubMed Score 9.67
PubMed score by year
PubTator Score 38.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title