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Tbio
PSMG1
Proteasome assembly chaperone 1

Protein Summary
Description
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331573
  • ENSP00000329915
  • ENSG00000183527
  • ENST00000380900
  • ENSP00000370286

Symbol
  • C21LRP
  • DSCR2
  • PAC1
  • PAC1
  • DSCR2
  • PAC-1
  • C21LRP
  • LRPC21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
histone modification site profile
0.88
disease perturbation
0.87
transcription factor binding site profile
0.84
cell type or tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.1   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.1   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
PSMG2
Tbio
Novelty:  0.11082503
p_int:  0.999999813
p_ni:  1.77e-7
p_wrong:  1e-8
Score:  0.959
Data Source:  BioPlex,STRINGDB
PSMA5
Tbio
Family:  Enzyme
Novelty:  0.03862668
p_int:  0.999997997
p_ni:  0.000002003
Score:  0.455
Data Source:  BioPlex,STRINGDB
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.999958767
p_ni:  0.000041233
Score:  0.869
Data Source:  BioPlex,STRINGDB
PSMB1
Tclin
Family:  Enzyme
Novelty:  0.0255917
p_int:  0.999315615
p_ni:  0.000684384
Score:  0.909
Data Source:  BioPlex,STRINGDB
PSMB3
Tbio
Family:  Enzyme
Novelty:  0.12791198
p_int:  0.998589237
p_ni:  0.001410763
Score:  0.809
Data Source:  BioPlex,STRINGDB
PSMB7
Tbio
Family:  Enzyme
Novelty:  0.06547657
p_int:  0.998337346
p_ni:  0.001662652
p_wrong:  2e-9
Score:  0.845
Data Source:  BioPlex,STRINGDB
PSMA1
Tclin
Family:  Enzyme
Novelty:  0.013722
p_int:  0.995557815
p_ni:  0.004442185
Score:  0.931
Data Source:  BioPlex,STRINGDB
SMAD7
Tbio
Family:  TF
Novelty:  0.00116343
p_int:  0.992985448
p_ni:  0.007014552
Data Source:  BioPlex
PSMB2
Tclin
Family:  Enzyme
Novelty:  0.06714761
p_int:  0.99292025
p_ni:  0.00707975
Score:  0.824
Data Source:  BioPlex,STRINGDB
CA10
Tbio
Family:  Enzyme
Novelty:  0.01053152
p_int:  0.944180362
p_ni:  0.055819638
Score:  0.529
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
4
3
4
85.2
4
2
1
1.3
84.6
fibrinogen measurement
4
2
4
72.7
2
2
0
1.2
72.2
total cholesterol measurement
1
1
1
71.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
4
85.2
1
1.3
84.6
fibrinogen measurement
4
72.7
0
1.2
72.2
total cholesterol measurement
1
71.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome assembly chaperone 1
VGNC:14679
473997
Macaque
proteasome assembly chaperone 1
715758
Mouse
MGI:1860263
56088
Rat
RGD:1305454
288236
Dog
proteasome assembly chaperone 1
VGNC:45121
608101
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome assembly chaperone 1
Macaque
proteasome assembly chaperone 1
Mouse
Rat
Dog
proteasome assembly chaperone 1
Publication Statistics
PubMed Score 12.10
PubMed score by year
PubTator Score 8.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title