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Tbio
PSMD6
26S proteasome non-ATPase regulatory subunit 6

Protein Summary
Description
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295901
  • ENSP00000295901
  • ENSG00000163636
  • ENST00000394431
  • ENSP00000377952
  • ENST00000482510
  • ENSP00000419227
  • ENST00000492933
  • ENSP00000418695

Symbol
  • KIAA0107
  • PFAAP4
  • S10
  • Rpn7
  • p42A
  • p44S10
  • SGA-113M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
biological process
0.98
hub protein
0.82
transcription factor binding site profile
0.75
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.36   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.36   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (343)
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
p_int:  0.999916314
p_ni:  0.000083686
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD13
Tbio
Family:  Enzyme
Novelty:  0.04204417
p_int:  0.999132868
p_ni:  0.000867132
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD7
Tbio
Family:  Enzyme
Novelty:  0.03090292
p_int:  0.997743368
p_ni:  0.002256632
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.995451103
p_ni:  0.004548897
Score:  0.999
Data Source:  BioPlex,STRINGDB
TMEM31
Tdark
Novelty:  0.65381391
p_int:  0.994869317
p_ni:  0.005130683
Data Source:  BioPlex
ADRM1
Tbio
Novelty:  0.01545209
p_int:  0.994809692
p_ni:  0.005190308
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.993174226
p_ni:  0.006825774
Score:  0.995
Data Source:  BioPlex,STRINGDB
UCHL5
Tbio
Family:  Enzyme
Novelty:  0.01486265
p_int:  0.987816744
p_ni:  0.012183256
Score:  0.992
Data Source:  BioPlex,STRINGDB
PSMB3
Tbio
Family:  Enzyme
Novelty:  0.12791198
p_int:  0.986461817
p_ni:  0.013538183
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCDC74B
Tdark
Novelty:  1.7435743
p_int:  0.980692098
p_ni:  0.019307902
Score:  0.689
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (158)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 149
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
6
4
1.1
95.5
glomerular filtration rate
2
2
2
77.6
red blood cell distribution width
1
1
1
48.5
1
1
0
1.1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
95.5
glomerular filtration rate
2
77.6
red blood cell distribution width
1
48.5
0
1.1
26.1
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 6
VGNC:14798
465457
Macaque
proteasome 26S subunit, non-ATPase 6
698601
Mouse
MGI:1913663
66413
Rat
RGD:735127
289924
Dog
proteasome 26S subunit, non-ATPase 6
VGNC:54345
484700
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 6
Macaque
proteasome 26S subunit, non-ATPase 6
Mouse
Rat
Dog
proteasome 26S subunit, non-ATPase 6
Publication Statistics
PubMed Score 21.36
PubMed score by year
PubTator Score 7.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title